MCPIP1 RNase Is Aberrantly Distributed in Psoriatic Epidermis and Rapidly Induced by IL-17A

Ester Ruiz-Romeu, Marta Ferran, Ana Giménez-Arnau, Beata Bugara, Barbara Lipert, Jolanta Jura, Edwin F. Florencia, Errol P. Prens, Antonio Celada, Ramon M. Pujol, Luis F. Santamaria-Babí

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Abstract

© 2016 The Authors ZC3H12A, which encodes the RNase monocyte chemotactic protein-induced protein 1 (MCPIP1), is up-regulated in psoriatic skin and reduced to normal levels after clinical treatments with anti–IL-17A/IL-17R neutralizing antibodies. In IL-17A–stimulated keratinocytes, MCPIP1 is rapidly increased at the transcript and protein levels. Also, IL-17A was found to be the main inducer of ZC3H12A expression in keratinocytes treated with supernatants derived from a Streptococcus pyogenes-activated psoriatic ex vivo model based on the co-culture of psoriatic cutaneous lymphocyte-associated antigen (CLA+) T cells and lesional epidermal cells. Moreover, MCPIP1 was aberrantly distributed in the suprabasal layers of psoriatic epidermis. In psoriatic samples, IL-17A–stimulated epidermal cell suspensions showed an increased MCPIP1 expression, especially in the mid-differentiated cellular compartment. The knockdown of ZC3H12A showed that this RNase participates in the regulation of the mRNAs present in suprabasal differentiated keratinocytes. Furthermore, JAK/STAT3 inhibition prevented the IL-17A–dependent induction of MCPIP1. In the mouse model of imiquimod-induced psoriasis, Zc3h12a expression was abrogated in Il17ra–/– mice. These results support the notion that IL-17A–mediated induction of MCPIP1 is involved in the regulation of local altered gene expression in suprabasal epidermal layers in psoriasis.
Original languageEnglish
Pages (from-to)1599-1607
JournalJournal of Investigative Dermatology
Volume136
Issue number8
DOIs
Publication statusPublished - 1 Aug 2016

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    Ruiz-Romeu, E., Ferran, M., Giménez-Arnau, A., Bugara, B., Lipert, B., Jura, J., Florencia, E. F., Prens, E. P., Celada, A., Pujol, R. M., & Santamaria-Babí, L. F. (2016). MCPIP1 RNase Is Aberrantly Distributed in Psoriatic Epidermis and Rapidly Induced by IL-17A. Journal of Investigative Dermatology, 136(8), 1599-1607. https://doi.org/10.1016/j.jid.2016.04.030