Matrix effects on the bioavailability of resveratrol in humans

Jordi Ortuño, Maria Isabel Covas, Magi Farre, Mitona Pujadas, Montserrat Fito, Olha Khymenets, Cristina Andres-Lacueva, Pere Roset, Jesús Joglar, Rosa M. Lamuela-Raventós, Rafael de la Torre

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72 Citations (Scopus)


The pharmacokinetics of resveratrol in 11 healthy male volunteers has been assessed in a randomized, crossover, controlled clinical trial after the administration of three grape products: red wine (250 mL), grape juice (1/L), or tablets (red wine extracts enriched with trans-resveratrol). Doses of trans-resveratrol independently of the product administered, were about 14 μg/kg. Biological samples were collected and analysed by capillary gas chromatography-mass spectrometry. cis-Resveratrol, trans-resveratrol and dihydroresveratrol were determined in plasma and urine. Plasma concentration of trans-resveratrol after hydrolysis increased as a response to all grape products and that of cis-resveratrol after wine and grape juice. Free forms of these phenolic compounds were deemed undetectable in plasma. Despite similar trans-resveratrol doses being administered, its bioavailability from wine and grape juice was 6-fold higher, than that from tablets. Resveratrol was better absorbed from natural grape products than from tablets, pointing out the importance of the matrix in its bioavailability. © 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)1123-1130
JournalFood Chemistry
Publication statusPublished - 15 Jun 2010


  • Grape juice
  • Grape products
  • Resveratrol
  • Resveratrol disposition
  • Wine


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