Abstract
© 2019, Springer Nature Switzerland AG. The majority of hypotheses suggested to explain the human immunodeficiency virus (HIV) progression explains the particularities of the disease by a very high mutability and evolvability of the virus. For HIV, several mechanisms of mutation are possible, and it is reasonable to assume that a mechanistic mathematical model of HIV evolution reflect these mechanisms. In this contribution, we formulate three different mathematical models of within-host HIV evolution that corresponds to three different virus mutation mechanisms. Simulations demonstrate that, for realistic rates of evolution, either of the three models leads to a very similar (and for some models to identical) outcome and, hence, only one of the mechanisms (presumably, the simplest one) can be used in simulations.
Original language | English |
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Title of host publication | Trends in Mathematics |
Pages | 27-34 |
Number of pages | 7 |
Volume | 11 |
ISBN (Electronic) | 2297-024X |
DOIs | |
Publication status | Published - 1 Jan 2019 |