Massive haemorrhage after bivalirudin anticoagulation in two heart transplant patients

M. Tauron; P. Paniagua; C. Muñoz-Guijosa; S. Mirabet; J. M. Padró

doi:10.1016/j.redar.2012.05.036

Massive haemorrhage after bivalirudin anticoagulation in two heart transplant patients

M. Tauron, P. Paniagua, C. Muñoz-Guijosa, S. Mirabet, J. M. Padró

Department of Surgery

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Heparin-induced thrombopenia is a common autoimmune complication. It is a prothrombotic state due to the formation of antibodies against heparin/platelet factor 4 complexes. In this situation drugs other than heparin must be used for anticoagulation during extracorporeal circulation (bypass) surgery.Two cases of heart transplantation are presented in whom bivalirudin was used as an anticoagulant during the cardiopulmonary bypass. Severe bleeding complications were observed in both patients.The diagnosis of heparin-induced thrombopenia needs to be improved, as well as the development of protocols for using new drugs other than heparin. For this reason, we have reviewed current protocols and alternative therapies to heparin. © 2011 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor.

Original language	English
Pages (from-to)	407-410
Journal	Revista Espanola de Anestesiologia y Reanimacion
Volume	60
Issue number	7
DOIs	https://doi.org/10.1016/j.redar.2012.05.036
Publication status	Published - 1 Aug 2013

Keywords

Anticoagulation
Bivalirudin
Bleeding
Extracorporeal circulation
Heart transplant
Heparin-induced thrombopenia

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10.1016/j.redar.2012.05.036

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title = "Massive haemorrhage after bivalirudin anticoagulation in two heart transplant patients",

abstract = "Heparin-induced thrombopenia is a common autoimmune complication. It is a prothrombotic state due to the formation of antibodies against heparin/platelet factor 4 complexes. In this situation drugs other than heparin must be used for anticoagulation during extracorporeal circulation (bypass) surgery.Two cases of heart transplantation are presented in whom bivalirudin was used as an anticoagulant during the cardiopulmonary bypass. Severe bleeding complications were observed in both patients.The diagnosis of heparin-induced thrombopenia needs to be improved, as well as the development of protocols for using new drugs other than heparin. For this reason, we have reviewed current protocols and alternative therapies to heparin. {\textcopyright} 2011 Sociedad Espa{\~n}ola de Anestesiolog{\'i}a, Reanimaci{\'o}n y Terap{\'e}utica del Dolor.",

keywords = "Anticoagulation, Bivalirudin, Bleeding, Extracorporeal circulation, Heart transplant, Heparin-induced thrombopenia",

author = "M. Tauron and P. Paniagua and C. Mu{\~n}oz-Guijosa and S. Mirabet and Padr{\'o}, {J. M.}",

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T1 - Massive haemorrhage after bivalirudin anticoagulation in two heart transplant patients

AU - Tauron, M.

AU - Paniagua, P.

AU - Muñoz-Guijosa, C.

AU - Mirabet, S.

AU - Padró, J. M.

PY - 2013/8/1

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AB - Heparin-induced thrombopenia is a common autoimmune complication. It is a prothrombotic state due to the formation of antibodies against heparin/platelet factor 4 complexes. In this situation drugs other than heparin must be used for anticoagulation during extracorporeal circulation (bypass) surgery.Two cases of heart transplantation are presented in whom bivalirudin was used as an anticoagulant during the cardiopulmonary bypass. Severe bleeding complications were observed in both patients.The diagnosis of heparin-induced thrombopenia needs to be improved, as well as the development of protocols for using new drugs other than heparin. For this reason, we have reviewed current protocols and alternative therapies to heparin. © 2011 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor.

KW - Anticoagulation

KW - Bivalirudin

KW - Bleeding

KW - Extracorporeal circulation

KW - Heart transplant

KW - Heparin-induced thrombopenia

U2 - 10.1016/j.redar.2012.05.036

DO - 10.1016/j.redar.2012.05.036

M3 - Article

VL - 60

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EP - 410

JO - Revista Espanola de Anestesiologia y Reanimacion

JF - Revista Espanola de Anestesiologia y Reanimacion

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