Mapping of the porcine oestrogen receptor 2 gene and association study with litter size in Iberian pigs

G. Muñoz; C. Óvilo; M. Amills; C. Rodríguez

doi:https://doi.org/10.1111/j.1365-2052.2004.01141.x

Mapping of the porcine oestrogen receptor 2 gene and association study with litter size in Iberian pigs

G. Muñoz, C. Óvilo, M. Amills, C. Rodríguez

Department of Animal and Food Science

Research output: Contribution to journal › Article › Research › peer-review

25 Citations (Scopus)

Abstract

Genes encoding the oestrogen receptors (ESR) are considered candidate genes for prolificacy traits due to the key role these molecules play in the regulation of reproductive physiology. In this paper, we report the assignment of the pig ESR2 gene to porcine chromosome 1 by radiation hybrid mapping. Most of the ESR2 cDNA was sequenced from Iberian pig ovarian RNA samples and one A/G single nucleotide polymorphism (SNP) was found at exon 5, being associated with a Met/Val substitution at position 949. This SNP was genotyped using a PCR-RFLP (Hsp9 2II) protocol and its potential effect on litter size was evaluated in two Iberian pig populations. However, no statistically significant association between the ESR2 polymorphism and litter size was found.

Original language	English
Pages (from-to)	242-244
Journal	Animal Genetics
Volume	35
DOIs	https://doi.org/10.1111/j.1365-2052.2004.01141.x
Publication status	Published - 1 Jun 2004

Keywords

Iberian pig
Litter size
Oestrogen receptor 2 gene

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https://doi.org/10.1111/j.1365-2052.2004.01141.x

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title = "Mapping of the porcine oestrogen receptor 2 gene and association study with litter size in Iberian pigs",

abstract = "Genes encoding the oestrogen receptors (ESR) are considered candidate genes for prolificacy traits due to the key role these molecules play in the regulation of reproductive physiology. In this paper, we report the assignment of the pig ESR2 gene to porcine chromosome 1 by radiation hybrid mapping. Most of the ESR2 cDNA was sequenced from Iberian pig ovarian RNA samples and one A/G single nucleotide polymorphism (SNP) was found at exon 5, being associated with a Met/Val substitution at position 949. This SNP was genotyped using a PCR-RFLP (Hsp9 2II) protocol and its potential effect on litter size was evaluated in two Iberian pig populations. However, no statistically significant association between the ESR2 polymorphism and litter size was found.",

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AU - Óvilo, C.

AU - Amills, M.

AU - Rodríguez, C.

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N2 - Genes encoding the oestrogen receptors (ESR) are considered candidate genes for prolificacy traits due to the key role these molecules play in the regulation of reproductive physiology. In this paper, we report the assignment of the pig ESR2 gene to porcine chromosome 1 by radiation hybrid mapping. Most of the ESR2 cDNA was sequenced from Iberian pig ovarian RNA samples and one A/G single nucleotide polymorphism (SNP) was found at exon 5, being associated with a Met/Val substitution at position 949. This SNP was genotyped using a PCR-RFLP (Hsp9 2II) protocol and its potential effect on litter size was evaluated in two Iberian pig populations. However, no statistically significant association between the ESR2 polymorphism and litter size was found.

AB - Genes encoding the oestrogen receptors (ESR) are considered candidate genes for prolificacy traits due to the key role these molecules play in the regulation of reproductive physiology. In this paper, we report the assignment of the pig ESR2 gene to porcine chromosome 1 by radiation hybrid mapping. Most of the ESR2 cDNA was sequenced from Iberian pig ovarian RNA samples and one A/G single nucleotide polymorphism (SNP) was found at exon 5, being associated with a Met/Val substitution at position 949. This SNP was genotyped using a PCR-RFLP (Hsp9 2II) protocol and its potential effect on litter size was evaluated in two Iberian pig populations. However, no statistically significant association between the ESR2 polymorphism and litter size was found.

KW - Iberian pig

KW - Litter size

KW - Oestrogen receptor 2 gene

U2 - https://doi.org/10.1111/j.1365-2052.2004.01141.x

DO - https://doi.org/10.1111/j.1365-2052.2004.01141.x

M3 - Article

SN - 0268-9146

VL - 35

SP - 242

EP - 244

JO - Animal Genetics

JF - Animal Genetics

ER -

Mapping of the porcine oestrogen receptor 2 gene and association study with litter size in Iberian pigs

Abstract

Keywords

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