TY - JOUR
T1 - Mapping of quantitative trait loci for cholesterol, LDL, HDL, and triglyceride serum concentrations in pigs
AU - Gallardo, David
AU - Pena, Ramona N.
AU - Amills, Marcel
AU - Varona, Luis
AU - Ramírez, Oscar
AU - Reixach, Josep
AU - Díaz, Isabel
AU - Tibau, Joan
AU - Soler, Joaquim
AU - Prat-Cuffi, Josep M.
AU - Noguera, José L.
AU - Quintanilla, Raquel
PY - 2008/11/1
Y1 - 2008/11/1
N2 - The fine mapping of polymorphisms influencing cholesterol (CT), triglyceride (TG), and lipoprotein serum levels in human and mouse has provided a wealth of knowledge about the complex genetic architecture of these traits. The extension of these genetic analyses to pigs would be of utmost importance since they constitute a valuable biological and clinical model for the study of coronary artery disease and myocardial infarction. In the present work, we performed a whole genome scan for serum lipid traits in a half-sib Duroc pig population of 350 individuals. Phenotypic registers included total CT, TG, and low (LDL)- and high (HDL)-density lipoprotein serum concentrations at 45 and 190 days of age. This approach allowed us to identify two genomewide significant quantitative trait loci (QTL) for HDL-to-LDL ratio at 45 days (SSC6, 84 cM) and for TG at 190 days (SSC4, 23 cM) as well as a number of chromosomewide significant QTL. The comparison of QTL locations at 45 and 190 days revealed a notable lack of concordance at these two time points, suggesting that the effects of these QTL are age specific. Moreover, we have observed a considerable level of correspondence among the locations of the most significant porcine lipid QTL and those identified in humans. This finding might suggest that, in mammals, diverse polymorphisms located in a common set of genes are involved in the genetic variation of serum lipid levels. Copyright © 2008 the American Physiological Society.
AB - The fine mapping of polymorphisms influencing cholesterol (CT), triglyceride (TG), and lipoprotein serum levels in human and mouse has provided a wealth of knowledge about the complex genetic architecture of these traits. The extension of these genetic analyses to pigs would be of utmost importance since they constitute a valuable biological and clinical model for the study of coronary artery disease and myocardial infarction. In the present work, we performed a whole genome scan for serum lipid traits in a half-sib Duroc pig population of 350 individuals. Phenotypic registers included total CT, TG, and low (LDL)- and high (HDL)-density lipoprotein serum concentrations at 45 and 190 days of age. This approach allowed us to identify two genomewide significant quantitative trait loci (QTL) for HDL-to-LDL ratio at 45 days (SSC6, 84 cM) and for TG at 190 days (SSC4, 23 cM) as well as a number of chromosomewide significant QTL. The comparison of QTL locations at 45 and 190 days revealed a notable lack of concordance at these two time points, suggesting that the effects of these QTL are age specific. Moreover, we have observed a considerable level of correspondence among the locations of the most significant porcine lipid QTL and those identified in humans. This finding might suggest that, in mammals, diverse polymorphisms located in a common set of genes are involved in the genetic variation of serum lipid levels. Copyright © 2008 the American Physiological Society.
KW - Candidate genes
KW - Lipid metabolism
KW - Lipoproteins
U2 - https://doi.org/10.1152/physiolgenomics.90249.2008
DO - https://doi.org/10.1152/physiolgenomics.90249.2008
M3 - Article
VL - 35
SP - 199
EP - 209
JO - Physiological Genomics
JF - Physiological Genomics
SN - 1094-8341
ER -
