Mapping, cloning and sequencing of a glycoprotein-encoding gene from bovine herpesvirus type 1 homologous to the gE gene from HSV-1

Xavier Rebordosa, Jaume Piñol, Josep A. Pérez-Pons, Jorge Lloberas, Jordi Naval, Enrique Querol

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

In order to map and identify the glycoprotein-encoding gene from bovine herpesvirus type 1 (BHV-1), homologous to the gE glycoprotein from herpes simplex virus type 1 (HSV-1), a region of the unique short sequence from the BHV-1 genome has been sequenced. The sequenced region contains an ORF coding for a polypeptide of 575 amino acids (aa). The aa sequence presents substantial similarity to that of the glycoprotein gE from HSV-1 and to homologous proteins of related viruses such as pseudorabies virus, equine herpesvirus type 1 and varicella zoster virus. The aa sequence presents additional characteristics compatible with the structure of a viral glycoprotein: signal peptide, putative glycosylation sites and a long C-terminal transmembrane α-helix. © 1994.
Original languageEnglish
Pages (from-to)203-209
JournalGene
Volume149
Issue number2
DOIs
Publication statusPublished - 18 Nov 1994

Keywords

  • BHV-1
  • gene expression
  • Gene identification
  • glycosylation
  • sequence homology
  • signal peptide
  • transmembrane domain
  • viral protein

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