Maniac symptoms in autoimmune encephalitis due to mGluR5 antibodies: Presentation of a case

Laura Martínez Sadurní, Sílvia Oller Canet, Daniel Bergé Baquero, José María Ginés Miranda, Purificación Salgado Serrano, Víctor Pérez Sola

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© 2019 Elsevier España, S.L.U. and Sociedad Española de Psiquiatría y Sociedad Española de Psiquiatría Biológica Autoimmune encephalitis is a heterogeneous entity in terms of its symptoms and prognosis. As the clinical presentation frequently includes psychiatric symptoms, the intervention of psychiatric services is usual in the diagnostic process, as well as in the management of the symptoms. The course of the disease is usually acute or rapidly progressive, making the early detection of this disease essential in patients in order to perform the complementary tests and to treat the origin. The case is presented of a 49 year-old man, with no psychiatric history, who presents with maniac symptoms in the emergency room. A few hours after being admitted to the inpatient unit he presents with decrease in consciousness level and fever. Complementary tests led to the diagnosis of autoimmune encephalitis with antibodies against the metabotropic receptor of glutamate 5. The psychiatric approach for symptomatic treatment was made by joint consultation.
Original languageEnglish
Pages (from-to)52-55
JournalPsiquiatria Biologica
Publication statusPublished - 1 May 2019


  • Affective disorders
  • Autoimmunity
  • Encephalitis
  • Mania
  • Neurology


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