Managing malignant cerebral infarction

J. Marc Simard, Joan Sahuquillo, Kevin N. Sheth, Kristopher T. Kahle, Brian P. Walcott

Research output: Contribution to journalReview articleResearchpeer-review

34 Citations (Scopus)

Abstract

Managing patients with malignant cerebral infarction remains one of the foremost challenges in medicine. These patients are at high risk for progressive neurologic deterioration and death due to malignant cerebral edema, and they are best cared for in the intensive care unit of a comprehensive stroke center. Careful initial assessment of neurologic function and of findings on MRI, coupled with frequent reassessment of clinical and radiologic findings using CT or MRI are mandatory to promote the prompt initiation of treatments that will ensure the best outcome in these patients. Significant deterioration in either neurologic function or radiologic findings or both demand timely treatment using the best medical management, which may include osmotherapy (mannitol or hypertonic saline), endotracheal intubation, and mechanical ventilation. Under appropriate circumstances, decompressive craniectomy may be warranted to improve outcome or to prevent death. © Springer Science+Business Media, LLC 2010.
Original languageEnglish
Pages (from-to)217-229
JournalCurrent Treatment Options in Neurology
Volume13
Issue number2
DOIs
Publication statusPublished - 1 Apr 2011

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