Management of sinonasal mucosal melanomas and comparison of classification staging systems

Juan R. Gras-Cabrerizo, Xavier León-Vintró, Margarita Majem Tarruella, Gabriel Pedemonte Sarria, Carolina Bothe Gonzalez, Joan R. Montserrat-Gili, Katherina Kolanczak, Humbert Massegur-Solench

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12 Citations (Scopus)


Copyright © 2015, OceanSide Publications, Inc., U.S.A. Objective: The aim of this study was to describe treatment results in patients with sinonasal mucosal melanomas (SMMs) and to compare three different classification staging systems. Materials and Methods: From 1988 to 2013, we performed a retrospective study of 20 patients with primary sinonasal melanomas. The median age at diagnosis was 71 years. There were 10 males and 10 females. Results: Nine SMMs (45%) were originated in the ethmoidal sinus complex, four (20%) in the inferior turbinate, three (15%) in the nasal septum, two (10%) in the maxillary sinus, and two (10%) in the nasal vestibule. Local recurrence was diagnosed in eight patients (40%), and six out of 20 patients (30%) developed distant metastasis during the course of their disease. The adjusted survival rates at three and five years were 47% and 34%, respectively. The adjusted three-year survival rate according to the sinonasal staging system 7th edition for SMM (TNM-SMM) was 60% in T3 stage, 50% in T4a stage, and 34% in T4b stage (p = 0.05). According to Thompson's staging system, survival was 33% for group one, 58% for group two, and 0% for group three (p = 0.006). With the sinonasal staging system 7th edition for carcinoma (TNM-CAR) survival was 33% in T1, 100% in T2 and T3, 0% in T4a, and 34% in T4b (p = 0.006). Conclusions: Our experience confirms the distribution of patients according to survival rates was better with the TNM-SMM than with Thompson's or the TNM-CAR systems.
Original languageEnglish
Pages (from-to)e37-e40
JournalAmerican Journal of Rhinology and Allergy
Issue number1
Publication statusPublished - 1 Jan 2015


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