TY - JOUR
T1 - Management of severe sepsis: Advances, challenges, and current status
AU - Martin-Loeches, Ignacio
AU - Levy, Mitchell M.
AU - Artigas, Antonio
PY - 2015/4/9
Y1 - 2015/4/9
N2 - © 2015 Martin-Loeches et al. The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and questions in the approach to pharmaceutical interventions for the global challenge to save lives and reduce healthcare costs. Therapeutic interventions including fluid resuscitation, hemodynamic monitoring, glycemic control, corticosteroids, and antimicrobial therapy and stewardship inform outcomes. Research on biomarkers, use of mesenchymal stem cells, blood purification, immunoglobulins, and antioxidative treatments apropos the immune response may soon yield viable therapies.
AB - © 2015 Martin-Loeches et al. The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and questions in the approach to pharmaceutical interventions for the global challenge to save lives and reduce healthcare costs. Therapeutic interventions including fluid resuscitation, hemodynamic monitoring, glycemic control, corticosteroids, and antimicrobial therapy and stewardship inform outcomes. Research on biomarkers, use of mesenchymal stem cells, blood purification, immunoglobulins, and antioxidative treatments apropos the immune response may soon yield viable therapies.
KW - Biomarkers
KW - Critical care
KW - Guidelines
KW - Sepsis
KW - Septic shock
KW - Surviving sepsis campaign
U2 - https://doi.org/10.2147/DDDT.S78757
DO - https://doi.org/10.2147/DDDT.S78757
M3 - Review article
VL - 9
SP - 2079
EP - 2088
JO - Drug Design, Development and Therapy
JF - Drug Design, Development and Therapy
SN - 1177-8881
ER -