Management of severe sepsis: Advances, challenges, and current status

Ignacio Martin-Loeches, Mitchell M. Levy, Antonio Artigas

Research output: Contribution to journalReview articleResearchpeer-review

55 Citations (Scopus)


© 2015 Martin-Loeches et al. The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and questions in the approach to pharmaceutical interventions for the global challenge to save lives and reduce healthcare costs. Therapeutic interventions including fluid resuscitation, hemodynamic monitoring, glycemic control, corticosteroids, and antimicrobial therapy and stewardship inform outcomes. Research on biomarkers, use of mesenchymal stem cells, blood purification, immunoglobulins, and antioxidative treatments apropos the immune response may soon yield viable therapies.
Original languageEnglish
Pages (from-to)2079-2088
JournalDrug Design, Development and Therapy
Publication statusPublished - 9 Apr 2015


  • Biomarkers
  • Critical care
  • Guidelines
  • Sepsis
  • Septic shock
  • Surviving sepsis campaign


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