Management of severe sepsis: Advances, challenges, and current status

Ignacio Martin-Loeches; Mitchell M. Levy; Antonio Artigas

doi:10.2147/DDDT.S78757

Management of severe sepsis: Advances, challenges, and current status

Ignacio Martin-Loeches, Mitchell M. Levy, Antonio Artigas

Department of Medicine

Research output: Contribution to journal › Review article › Research › peer-review

43 Citations (Scopus)

Abstract

© 2015 Martin-Loeches et al. The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and questions in the approach to pharmaceutical interventions for the global challenge to save lives and reduce healthcare costs. Therapeutic interventions including fluid resuscitation, hemodynamic monitoring, glycemic control, corticosteroids, and antimicrobial therapy and stewardship inform outcomes. Research on biomarkers, use of mesenchymal stem cells, blood purification, immunoglobulins, and antioxidative treatments apropos the immune response may soon yield viable therapies.

Original language	English
Pages (from-to)	2079-2088
Journal	Drug Design, Development and Therapy
Volume	9
DOIs	https://doi.org/10.2147/DDDT.S78757
Publication status	Published - 9 Apr 2015

Keywords

Biomarkers
Critical care
Guidelines
Sepsis
Septic shock
Surviving sepsis campaign

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10.2147/DDDT.S78757

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Martin-Loeches, I., Levy, M. M., & Artigas, A. (2015). Management of severe sepsis: Advances, challenges, and current status. Drug Design, Development and Therapy, 9, 2079-2088. https://doi.org/10.2147/DDDT.S78757

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