Management of NSAID-associated peptic ulcer disease

Luigi Melcarne; Pilar García-Iglesias; Xavier Calvet

doi:10.1586/17474124.2016.1142872

Management of NSAID-associated peptic ulcer disease

Luigi Melcarne, Pilar García-Iglesias, Xavier Calvet

Department of Medicine

Research output: Contribution to journal › Review article › Research › peer-review

44 Citations (Scopus)

Abstract

© 2016 Informa UK Limited, trading as Taylor & Francis Group. ABSTRACT: Non-steroidal anti-inflammatory drug (NSAID) use increases the risk of gastrointestinal complications such as ulcers or bleeding. The presence of factors like advanced age, history of peptic ulcer, Helicobacter pylori infection and the use of anticoagulants or antiplatelet agents increase this risk further. COX-2 inhibitors and antisecretory drugs, particularly proton pump inhibitors, help to minimize the risk of gastrointestinal complications in high-risk patients. This review presents a practical approach to the prevention and treatment of NSAID-associated peptic ulcer disease and examines the new advances in the rational use of NSAIDs.

Original language	English
Pages (from-to)	723-733
Journal	Expert Review of Gastroenterology and Hepatology
Volume	10
Issue number	6
DOIs	https://doi.org/10.1586/17474124.2016.1142872
Publication status	Published - 2 Jun 2016

Keywords

Cardiovascular risk
COX-2 selective inhibitors
Gastrointestinal bleeding
Gastrointestinal risk
Gastroprotection
Low dose aspirin
Non-steroidal anti-inflammatory drugs
NSAID gastropathy
Upper gastrointestinal complications

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title = "Management of NSAID-associated peptic ulcer disease",

abstract = "{\textcopyright} 2016 Informa UK Limited, trading as Taylor & Francis Group. ABSTRACT: Non-steroidal anti-inflammatory drug (NSAID) use increases the risk of gastrointestinal complications such as ulcers or bleeding. The presence of factors like advanced age, history of peptic ulcer, Helicobacter pylori infection and the use of anticoagulants or antiplatelet agents increase this risk further. COX-2 inhibitors and antisecretory drugs, particularly proton pump inhibitors, help to minimize the risk of gastrointestinal complications in high-risk patients. This review presents a practical approach to the prevention and treatment of NSAID-associated peptic ulcer disease and examines the new advances in the rational use of NSAIDs.",

keywords = "Cardiovascular risk, COX-2 selective inhibitors, Gastrointestinal bleeding, Gastrointestinal risk, Gastroprotection, Low dose aspirin, Non-steroidal anti-inflammatory drugs, NSAID gastropathy, Upper gastrointestinal complications",

author = "Luigi Melcarne and Pilar Garc{\'i}a-Iglesias and Xavier Calvet",

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doi = "10.1586/17474124.2016.1142872",

language = "English",

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T1 - Management of NSAID-associated peptic ulcer disease

AU - Melcarne, Luigi

AU - García-Iglesias, Pilar

AU - Calvet, Xavier

PY - 2016/6/2

Y1 - 2016/6/2

N2 - © 2016 Informa UK Limited, trading as Taylor & Francis Group. ABSTRACT: Non-steroidal anti-inflammatory drug (NSAID) use increases the risk of gastrointestinal complications such as ulcers or bleeding. The presence of factors like advanced age, history of peptic ulcer, Helicobacter pylori infection and the use of anticoagulants or antiplatelet agents increase this risk further. COX-2 inhibitors and antisecretory drugs, particularly proton pump inhibitors, help to minimize the risk of gastrointestinal complications in high-risk patients. This review presents a practical approach to the prevention and treatment of NSAID-associated peptic ulcer disease and examines the new advances in the rational use of NSAIDs.

AB - © 2016 Informa UK Limited, trading as Taylor & Francis Group. ABSTRACT: Non-steroidal anti-inflammatory drug (NSAID) use increases the risk of gastrointestinal complications such as ulcers or bleeding. The presence of factors like advanced age, history of peptic ulcer, Helicobacter pylori infection and the use of anticoagulants or antiplatelet agents increase this risk further. COX-2 inhibitors and antisecretory drugs, particularly proton pump inhibitors, help to minimize the risk of gastrointestinal complications in high-risk patients. This review presents a practical approach to the prevention and treatment of NSAID-associated peptic ulcer disease and examines the new advances in the rational use of NSAIDs.

KW - Cardiovascular risk

KW - COX-2 selective inhibitors

KW - Gastrointestinal bleeding

KW - Gastrointestinal risk

KW - Gastroprotection

KW - Low dose aspirin

KW - Non-steroidal anti-inflammatory drugs

KW - NSAID gastropathy

KW - Upper gastrointestinal complications

U2 - 10.1586/17474124.2016.1142872

DO - 10.1586/17474124.2016.1142872

M3 - Review article

SN - 1747-4124

VL - 10

SP - 723

EP - 733

JO - Expert Review of Gastroenterology and Hepatology

JF - Expert Review of Gastroenterology and Hepatology

IS - 6

ER -

Management of NSAID-associated peptic ulcer disease

Abstract

Keywords

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