Management costs of chest and CNS-related adverse events associated with the treatment of acute migraine attacks with oral triptans

John Slof, X. Badia, J. M. Láinez, J. Galván, J. Heras

    Research output: Contribution to journalArticleResearchpeer-review

    7 Citations (Scopus)

    Abstract

    Introduction. Although adverse events of triptans are usually not important from a clinical point of view, they can worry patients and lead them to consume healthcare resources. Methods. A decision analytic model was used to represent the behavior and management of patients who suffered adverse events after taking a triptan. Using data about the incidence of adverse events, the behavior and management of patients, and the unit cost of the healthcare resource consumed, the costs of treating adverse events were calculated, as was the iatrogenic cost factor of the triptans available in Spain. Results. 10% to 20% of patients who suffer a chest or CNS-related adverse advent related to triptan use seek medical attention. The management cost of a chest-related event was estimated to be € 66.43, € 33.09, or € 137.01, depending on whether the patient consulted a neurologist, a primary care physician, or a hospital emergency department. For CNS-related events the management cost was estimated to be € 52.88, € 16.89 or € 102.17, respectively. Excluding the placebo effect, the resulting iatrogenic cost factor varied between 1 for almotriptan 12.5 mg and 1.21 for zolmitriptan 2.5 mg. In absolute values, the average cost per patient (above placebo) varied between 0 € for almotriptan 12.5 mg and € 1.17 for eletriptan 80 mg. Conclusions. The management of adverse events can add substantial costs to a treatment with triptans. These costs vary considerably between triptans due to differences in the incidence of adverse events. Lowest costs were found for almotriptan 12.5 mg.
    Original languageEnglish
    Pages (from-to)290-298
    JournalNeurologia
    Volume20
    Issue number6
    Publication statusPublished - 1 Jul 2005

    Keywords

    • Adverse event
    • Costs
    • Iatrogenic cost factor
    • Migraine
    • Triptan

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