Mammalian Meiotic Recombination: A Toolbox for Genome Evolution

Laia Capilla, Montserrat Garcia Caldés, Aurora Ruiz-Herrera

Research output: Contribution to journalReview articleResearchpeer-review

12 Citations (Scopus)

Abstract

© 2016 S. Karger AG, Basel. Meiotic recombination is a process that increases genetic diversity and is fundamental for sexual reproduction. Determining by which mechanisms genetic variation is generated and maintained across different phylogenetic groups provides the basis for our understanding of biodiversity and evolution. In this review, we go through different aspects of this essential phenomenon, paying special attention to mammals. We provide a comprehensive view on the organization of meiotic chromosomes and the mechanisms involved in the formation and genomic distribution of recombination hotspots, focusing on the factors influencing the formation and repair of the massive amount of self-induced DNA breaks in early stages of meiosis. At the same time, we discuss the genetic and mechanistic factors that influence recombination landscapes in mammals, as reflected by several layers of regulation. These factors include the selective forces that affect the DNA sequence itself, which can be modulated by genome reshuffling and the evolutionary history of each taxon, and the forces that control how the DNA is packaged into chromosomes during meiosis.
Original languageEnglish
Pages (from-to)1-16
JournalCytogenetic and Genome Research
Volume150
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Crossovers
  • Evolution
  • Meiosis
  • PRDM9
  • Recombination

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