Abstract
A 73-year-old woman presented with an hemorrhagic kidney tumor initially interpreted as a renal cell carcinoma (RCG). A retroperitoneal recurrence infiltrating the duodenal wall was made up of dear cells, some of which contained Fontana-Masson positive pigment, immunopositive for HMB-45, S-100 protein, actin, and vimentin. The same immunohistochemical profile was retrospectively reproduced in the kidney minor, where melanosomes were also found ultrastructurally. Lipomatous differentiation was not observed. There was no history of malignant melanoma (MM), or stigmata of tuberous sclerosis. The patient died of disease 5 years after the initial diagnosis. This neoplasm can be considered as a malignant, pigmented, clear-cell epithelioid variant of angiomyolipoma, or 'sugar' tumor of the kidney, with the peculiarity of having a previously unreported component of pigmented cells visible on light microscopy. This finding raises the possibility that the exceptional cases of MM reported in renal parenchyma may be pigmented variants of epithelioid angiomyolipoma rather than true MM. Copyright (C) 2000 by W.B. Saunders Company.
Original language | English |
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Pages (from-to) | 516-519 |
Journal | Human Pathology |
Volume | 31 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Jan 2000 |
Keywords
- 'sugar' tumor
- Angiomyolipoma
- Clear cell tumors
- Kidney minors
- Malignant melanoma
- Melanin