Two patients are presented with lymphadenopathy, hepatosplenomegaly and infiltration of the bone marrow with plasmocytoid cells in whom a heterogeneous hyperimmunoglobulinemia was detected (3.18 and 5.85 g/100/ml). Autopsy showed widespread poorly differentiated lymphocytic lymphoma with plasmocytoid differentiation in one case and well differentiated lymphocytic lymphoma with plasmocytoid differentiation involving lymph nodes, marrow, spleen, liver and kidney in the other. High concentrations of IgM and IgG were detected in lymph node and spleen homogenates from the latter case. After splenectomy and cyclophosphamide the immunoglobulins decreased. It is suggested that both cases had a malignant lymphoma with plasmocytoid differentiation and polyclonal gammopathy.
Guardia, J., Pedreira, J. D., Vidal, M. T., & Roca, A. (1976). Malignant lymphoma with plasmacytoid differentiation and polyclonal gammopathy. Acta Haematologica, 55(6), 346-353. https://doi.org/10.1159/000208039