TY - JOUR
T1 - Malignancy and myositis, from molecular mimicry to tumor infiltrating lymphocytes
AU - Selva-O'Callaghan, Albert
AU - Ros, Javier
AU - Gil-Vila, Albert
AU - Vila-Pijoan, Gemma
AU - Trallero-Araguás, Ernesto
AU - Pinal-Fernandez, Iago
N1 - Copyright © 2019 Elsevier B.V. All rights reserved.
PY - 2019/11
Y1 - 2019/11
N2 - © 2019 Elsevier B.V. Cancer-associated dermatomyositis provides a unique opportunity to explore the relationship between autoimmunity and cancer. In this review, we describe the related epidemiological issues, considering the various currently accepted myositis phenotypes, their link with cancer, and the possible mechanisms leading to this relationship. We discuss current evidence regarding the role of molecular mimicry, somatic DNA tumor mutations, and the PD-1/PD-L1 pathway in the association between cancer and myositis. We also review tumor-infiltrating lymphocytes as a relevant factor to be evaluated in cancer-associated myositis, their interaction with tumor neoantigens, and the tumor mutational burden, all of which have implications for the treatment of these patients with immunotherapy. Finally, we discuss clinical scenarios related to the relationship between cancer and myositis, delineating a comprehensive theory linking autoimmunity and cancer.
AB - © 2019 Elsevier B.V. Cancer-associated dermatomyositis provides a unique opportunity to explore the relationship between autoimmunity and cancer. In this review, we describe the related epidemiological issues, considering the various currently accepted myositis phenotypes, their link with cancer, and the possible mechanisms leading to this relationship. We discuss current evidence regarding the role of molecular mimicry, somatic DNA tumor mutations, and the PD-1/PD-L1 pathway in the association between cancer and myositis. We also review tumor-infiltrating lymphocytes as a relevant factor to be evaluated in cancer-associated myositis, their interaction with tumor neoantigens, and the tumor mutational burden, all of which have implications for the treatment of these patients with immunotherapy. Finally, we discuss clinical scenarios related to the relationship between cancer and myositis, delineating a comprehensive theory linking autoimmunity and cancer.
KW - Autoimmunity
KW - Cancer
KW - Dermatomyositis
KW - Molecular mimicry
KW - Myositis
KW - PD-1/PD-L1 tumor-infiltrating lymphocytes
UR - http://www.mendeley.com/research/malignancy-myositis-molecular-mimicry-tumor-infiltrating-lymphocytes
U2 - 10.1016/j.nmd.2019.09.014
DO - 10.1016/j.nmd.2019.09.014
M3 - Review article
C2 - 31635909
SN - 0960-8966
VL - 29
SP - 819
EP - 825
JO - Neuromuscular Disorders
JF - Neuromuscular Disorders
IS - 11
ER -
