Malformations induced by vitamin A administered in the young chick blastoderm

X. Gonzalez Compta, J. M. Domenech Mateu

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The administration of 2250 IU of retinyl palmitate in young chick blastoderm at 4-5 HH stage brings 28% of surviving embryos and 84.5% malformed. The most frequent induced anomalies affect neural tube and/or neural crest which are the most sensible structures to vitamin A teratogenic action. The teratogenic mechanism would be produced by direct effect upon neuroblast and neural crest cells, and thus, this would cause the usual association of neural tube closure defects with facial malformations.
Original languageEnglish
Pages (from-to)9-13
JournalBulletin de l'Association des Anatomistes
Volume78
Issue number240
Publication statusPublished - 1 Jan 1994

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