Macroorchidism and panhypopituitarism: Two different forms of presentation of FSH-secreting pituitary adenomas in adolescence

María Clemente, Fabiola Caracseghi, Miquel Gussinyer, Diego Yeste, Marian Albisu, Elida Vázquez, Arantxa Ortega, Antonio Carrascosa

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19 Citations (Scopus)


Background: FSH-secreting pituitary adenomas are extremely rare in children and are seldom associated with clinical manifestations of high serum gonadotrophin levels. Thus, most patients have a late presentation, usually as macroadenomas. Case Reports: Two different clinical forms of presentation of FSH-secreting pituitary adenomas are reported: one in a 12-year-old boy with macroorchidism due to a pituitary microadenoma, probably FSH-secreting, and the other in a 15-year-old boy with panhypopituitarism due to an FSH-producing macroadenoma. Both patients presented slightly high or high FSH with low LH and high inhibin B levels. In the first case, the microadenoma was treated medically with cabergoline, which failed to reduce FSH and inhibin B levels. No radiological progression has been observed despite increasing testicular volume. In the second case, surgery was performed on the macroadenoma, leading to a decrease in FSH and inhibin B levels. The patient developed severe hypothalamic obesity and is currently under treatment with somatostatin. Conclusions: FSH-secreting pituitary tumors have an extremely variable clinical expression. The discrepancy between normal or slightly increased FSH and low LH values, together with high inhibin B levels, strongly suggests FSH hypersecretion which should be studied. Copyright © 2010 S. Karger AG.
Original languageEnglish
Pages (from-to)225-230
JournalHormone Research in Paediatrics
Issue number3
Publication statusPublished - 1 Mar 2011


  • FSH pituitary adenoma
  • Gonadotroph adenoma
  • Inhibin B


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