This chapter presents a new methodology to detect Down's syndrome during the second-trimester of gestation. We propose a Fuzzy Logic based classification method that is able of both improving the classification accuracy of the existing screening methods and extracting a set of intelligible rules that explain the system found. The accuracy is improved by reducing the False Positive rate up to 3%-4%, with a 60% of True Positive rate. Never before a screening method could reduce the FP rate below 5%, with a 60% of TP. The intelligibility is obtained by getting a reduced set of rules, expressed in a fuzzy way, which helps to explain the knowledge contained in the classification system found. Finally, conclude that the medical staff was able to understand the system expressed in the Fuzzy rules found, where its number of rules is just 10. © 2009 Nova Science Publishers, Inc. All rights reserved.
|Title of host publication||Handbook of Down Syndrome Research|
|Number of pages||15|
|Publication status||Published - 1 Dec 2009|