Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity

Marion David; Irma Machuca-Gayet; Junichi Kikuta; Penelope Ottewell; Fuka Mima; Raphael Leblanc; Edith Bonnelye; Johnny Ribeiro; Ingunn Holen; Rùben Lopez Vales; Pierre Jurdic; Jerold Chun; Philippe Clézardin; Masaru Ishii; Olivier Peyruchaud

doi:10.1074/jbc.M113.533232

Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity

Marion David, Irma Machuca-Gayet, Junichi Kikuta, Penelope Ottewell, Fuka Mima, Raphael Leblanc, Edith Bonnelye, Johnny Ribeiro, Ingunn Holen, Rùben Lopez Vales, Pierre Jurdic, Jerold Chun, Philippe Clézardin, Masaru Ishii, Olivier Peyruchaud

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Abstract

Background: Lysophosphatidic acid (LPA) is a bioactive lipid with pleiotropic activities due to activation of six receptors (LPA1-6). Results: Genetic deletion and pharmacological blockade of LPA1 inhibit differentiation and bone degradation activity of osteoclasts. Conclusion: LPA controls bone homeostasis through the activation of LPA1 expressed by osteoclasts. Significance: LPA1 is a new therapeutic target of diseases with excess bone degradation. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Original language	English
Pages (from-to)	6551-6564
Journal	Journal of Biological Chemistry
Volume	289
Issue number	10
DOIs	https://doi.org/10.1074/jbc.M113.533232
Publication status	Published - 7 Mar 2014

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David, M., Machuca-Gayet, I., Kikuta, J., Ottewell, P., Mima, F., Leblanc, R., Bonnelye, E., Ribeiro, J., Holen, I., Vales, R. L., Jurdic, P., Chun, J., Clézardin, P., Ishii, M., & Peyruchaud, O. (2014). Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. Journal of Biological Chemistry, 289(10), 6551-6564. https://doi.org/10.1074/jbc.M113.533232

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title = "Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity",

abstract = "Background: Lysophosphatidic acid (LPA) is a bioactive lipid with pleiotropic activities due to activation of six receptors (LPA1-6). Results: Genetic deletion and pharmacological blockade of LPA1 inhibit differentiation and bone degradation activity of osteoclasts. Conclusion: LPA controls bone homeostasis through the activation of LPA1 expressed by osteoclasts. Significance: LPA1 is a new therapeutic target of diseases with excess bone degradation. {\textcopyright} 2014 by The American Society for Biochemistry and Molecular Biology, Inc.",

author = "Marion David and Irma Machuca-Gayet and Junichi Kikuta and Penelope Ottewell and Fuka Mima and Raphael Leblanc and Edith Bonnelye and Johnny Ribeiro and Ingunn Holen and Vales, {R{\`u}ben Lopez} and Pierre Jurdic and Jerold Chun and Philippe Cl{\'e}zardin and Masaru Ishii and Olivier Peyruchaud",

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David, M, Machuca-Gayet, I, Kikuta, J, Ottewell, P, Mima, F, Leblanc, R, Bonnelye, E, Ribeiro, J, Holen, I, Vales, RL, Jurdic, P, Chun, J, Clézardin, P, Ishii, M & Peyruchaud, O 2014, 'Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity', Journal of Biological Chemistry, vol. 289, no. 10, pp. 6551-6564. https://doi.org/10.1074/jbc.M113.533232

TY - JOUR

T1 - Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity

AU - David, Marion

AU - Machuca-Gayet, Irma

AU - Kikuta, Junichi

AU - Ottewell, Penelope

AU - Mima, Fuka

AU - Leblanc, Raphael

AU - Bonnelye, Edith

AU - Ribeiro, Johnny

AU - Holen, Ingunn

AU - Vales, Rùben Lopez

AU - Jurdic, Pierre

AU - Chun, Jerold

AU - Clézardin, Philippe

AU - Ishii, Masaru

AU - Peyruchaud, Olivier

PY - 2014/3/7

Y1 - 2014/3/7

N2 - Background: Lysophosphatidic acid (LPA) is a bioactive lipid with pleiotropic activities due to activation of six receptors (LPA1-6). Results: Genetic deletion and pharmacological blockade of LPA1 inhibit differentiation and bone degradation activity of osteoclasts. Conclusion: LPA controls bone homeostasis through the activation of LPA1 expressed by osteoclasts. Significance: LPA1 is a new therapeutic target of diseases with excess bone degradation. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

AB - Background: Lysophosphatidic acid (LPA) is a bioactive lipid with pleiotropic activities due to activation of six receptors (LPA1-6). Results: Genetic deletion and pharmacological blockade of LPA1 inhibit differentiation and bone degradation activity of osteoclasts. Conclusion: LPA controls bone homeostasis through the activation of LPA1 expressed by osteoclasts. Significance: LPA1 is a new therapeutic target of diseases with excess bone degradation. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

U2 - 10.1074/jbc.M113.533232

DO - 10.1074/jbc.M113.533232

M3 - Article

SN - 0021-9258

VL - 289

SP - 6551

EP - 6564

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 10

ER -

Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity

Abstract

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