Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity

Marion David, Irma Machuca-Gayet, Junichi Kikuta, Penelope Ottewell, Fuka Mima, Raphael Leblanc, Edith Bonnelye, Johnny Ribeiro, Ingunn Holen, Rùben Lopez Vales, Pierre Jurdic, Jerold Chun, Philippe Clézardin, Masaru Ishii, Olivier Peyruchaud

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Abstract

Background: Lysophosphatidic acid (LPA) is a bioactive lipid with pleiotropic activities due to activation of six receptors (LPA1-6). Results: Genetic deletion and pharmacological blockade of LPA1 inhibit differentiation and bone degradation activity of osteoclasts. Conclusion: LPA controls bone homeostasis through the activation of LPA1 expressed by osteoclasts. Significance: LPA1 is a new therapeutic target of diseases with excess bone degradation. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Original languageEnglish
Pages (from-to)6551-6564
JournalJournal of Biological Chemistry
Volume289
Issue number10
DOIs
Publication statusPublished - 7 Mar 2014

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