Among 27 patients affected by lymphocytic lymphoma the authors observed 4 with signs of meningeal involvement characterized by paralysis of cranial nerves, low glucose levels and pleocytosis (from 290 to 5,200 per mm 3) with atypical lymphoma cells in the cerebrospinal fluid. Electroencephalography and 99Tc gammography were not very useful in diagnosis. The lymphomatous leptomeningitis was not accompanied by invasion of the bone marrow in any of the 4 patients. These were treated with intrathecal methotrexate, with remission of the neurological manifestations which were very transient. The authors indicate that the high incidence of leptomeningitis (14.8%) among their cases could be caused, as in the leukemias, by the greater survival obtained in lymphomas with the current treatments.
|Publication status||Published - 1 Dec 1974|