Lymphoid neogenesis in chronic inflammatory diseases

Francesca Aloisi, Ricardo Pujol-Borrell

    Research output: Contribution to journalReview articleResearchpeer-review

    643 Citations (Scopus)

    Abstract

    The frequent observation of organized lymphoid structures that resemble secondary lymphoid organs in tissues that are targeted by chronic inflammatory processes, such as autoimmunity and infection, has indicated that lymphoid neogenesis might have a role in maintaining immune responses against persistent antigens. In this Review, we discuss recent progress in several aspects of lymphoid neogenesis, focusing on the similarities with lymphoid tissue development, the mechanisms of induction, functional competence and pathophysiological significance. As more information on these issues becomes available, a better understanding of the role of lymphoid neogenesis in promoting chronic inflammation might eventually lead to new strategies to target immunopathological processes.
    Original languageEnglish
    Pages (from-to)205-217
    JournalNature Reviews Immunology
    Volume6
    Issue number3
    DOIs
    Publication statusPublished - 1 Mar 2006

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