Lymph Node Ratio Nomogram-Based Prognostic Model for Resected Distal Cholangiocarcinoma

Marc Perez, Carsten Palnaes Hansen, Fernando Burdio, Gianluca Pellino, Adolfo Pisanu, Roberto Salvia, Marcello Di Martino, Mohammad Abu Hilal, Luca Aldrighetti, Benedetto Ielpo*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review


BACKGROUND: Several variables have been described as prognostic factors for resected distal cholangiocarcinoma (dCC), including lymph node metastases (N status) and lymph node ratio (LNR). The present study aimed to evaluate the prognostic value of LNR on survival and to establish a novel prognostic nomogram to predict the cancer-specific recurrence-free survival (RFS) of dCC. STUDY DESIGN: Between December 2006 and September 2020, 415 consecutive patients who underwent pancreaticoduodenectomy (PD) for dCC in 10 centers were identified. Multivariate Cox analysis was used to identify all independent risk factors among several prognostic factors. A nomogram was then developed and assessed by integrating the independent prognostic factors into the model, and the concordance index (C-index) was used to evaluate its performance. RESULTS: According to Cox regression multivariate analysis, a nomogram based on independent prognostic factor for RFS was performed including LNR 15 (hazard ratio [HR] 2.442, 95% CI 1.348–4.425, p = 0.003), perineural invasion (HR 3.100, 95% CI 1.183–8.122, p = 0.025), differentiation grade (HR 2.100, 95% CI 1.172–4.143, p = 0.021), and radicality of PD (HR 2.276, 95% CI 1.223–4.234, p = 0.009). The C-index of the nomogram, tailored based on the previous significant factors, was 0.8. CONCLUSIONS: LNR15 yields a high prognostic efficiency for RFS. The nomogram based on LNR can provide an accurate prognosis assessment for patients with resected dCC.

Original languageEnglish
Pages (from-to)703-712
Number of pages10
JournalJournal of the American College of Surgeons
Issue number5
Publication statusPublished - 1 Nov 2022


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