Lung transplantation in two cystic fibrosis patients infected with previously pandrug-resistant Burkholderia cepacia complex treated with ceftazidime–avibactam

Ibai Los-Arcos, Oscar Len, María Teresa Martín-Gómez, Juan José González-López, Berta Saéz-Giménez, María Deu, Xavier Nuvials, Ricard Ferrer, Antonio Román, Joan Gavaldà

Research output: Contribution to journalArticleResearch

3 Citations (Scopus)

Abstract

© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. We describe two cystic fibrosis patients infected with pandrug-resistant Burkholderia cepacia complex, with the exception of ceftazidime–avibactam, who received prophylaxis with this antibiotic during lung transplantation. Although both patients had a post-operative relapse of respiratory infection, one with positive blood cultures, ceftazidime–avibactam treatment yielded a favourable outcome. 12 months after transplantation, one patient presented an excellent clinical outcome. However, the other patient died 10 months later due to severe B. cepacia sinusitis with intracranial invasion.
Original languageEnglish
Pages (from-to)289-292
JournalInfection
Volume47
DOIs
Publication statusPublished - 5 Apr 2019

Keywords

  • Burkholderia cepacia complex
  • Ceftazidime–avibactam
  • Cystic fibrosis
  • Lung transplantation
  • Multi-drug resistance
  • Respiratory tract infection

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