TY - JOUR
T1 - Lung transplantation in two cystic fibrosis patients infected with previously pandrug-resistant Burkholderia cepacia complex treated with ceftazidime–avibactam
AU - Los-Arcos, Ibai
AU - Len, Oscar
AU - Martín-Gómez, María Teresa
AU - González-López, Juan José
AU - Saéz-Giménez, Berta
AU - Deu, María
AU - Nuvials, Xavier
AU - Ferrer, Ricard
AU - Román, Antonio
AU - Gavaldà, Joan
PY - 2019/4/5
Y1 - 2019/4/5
N2 - © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. We describe two cystic fibrosis patients infected with pandrug-resistant Burkholderia cepacia complex, with the exception of ceftazidime–avibactam, who received prophylaxis with this antibiotic during lung transplantation. Although both patients had a post-operative relapse of respiratory infection, one with positive blood cultures, ceftazidime–avibactam treatment yielded a favourable outcome. 12 months after transplantation, one patient presented an excellent clinical outcome. However, the other patient died 10 months later due to severe B. cepacia sinusitis with intracranial invasion.
AB - © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. We describe two cystic fibrosis patients infected with pandrug-resistant Burkholderia cepacia complex, with the exception of ceftazidime–avibactam, who received prophylaxis with this antibiotic during lung transplantation. Although both patients had a post-operative relapse of respiratory infection, one with positive blood cultures, ceftazidime–avibactam treatment yielded a favourable outcome. 12 months after transplantation, one patient presented an excellent clinical outcome. However, the other patient died 10 months later due to severe B. cepacia sinusitis with intracranial invasion.
KW - Burkholderia cepacia complex
KW - Ceftazidime–avibactam
KW - Cystic fibrosis
KW - Lung transplantation
KW - Multi-drug resistance
KW - Respiratory tract infection
U2 - 10.1007/s15010-018-1261-y
DO - 10.1007/s15010-018-1261-y
M3 - Article
C2 - 30565008
VL - 47
SP - 289
EP - 292
ER -