Lung transplantation in children. Specific aspects

Research output: Contribution to journalReview articleResearchpeer-review


Lung transplantation has become in recent years a therapeutic option for infantswith terminal lung disease with similar results to transplantation in adults.In Spain, since 1996 114 children lung transplants have been performed; this corresponds to3.9% of the total transplant number.The most common indication in children is cystic fibrosis, which represents between 70-80% of the transplants performed in adolescents. In infants common indications areinterstitial lung disease and pulmonary hypertension.In most children a sequential double lung transplant is performed, generally with the help ofextracorporeal circulation. Lung transplantation in children presents special challenges in monitoring and follow-up, especially in infants, given the difficulty in assessing lung function and performing transbronchial biopsies.There are some more specific complications in children like postransplant lymphoproliferative syndrome or a greater severity of respiratory virus infections .After lung transplantation children usually experiment a very important improvement in their quality of life. Eighty eight per cent of children have no limitations in their activity after 3 years of transplantation.According to the registry of the International Society for Heart & Lung Transplantation (ISHLT) survival at 5 years of transplantation is 54% and at 10 years is around 35%.

Original languageEnglish
Pages (from-to)523-8
Number of pages6
JournalArchivos de bronconeumologia
Issue number12
Publication statusPublished - Dec 2013


  • Adolescent
  • Child
  • Child, Preschool
  • Contraindications
  • Cystic Fibrosis/surgery
  • Epstein-Barr Virus Infections/complications
  • Extracorporeal Circulation
  • Graft Rejection/prevention & control
  • Graft vs Host Disease/prevention & control
  • Humans
  • Hypertension, Pulmonary/surgery
  • Immunosuppressive Agents/therapeutic use
  • Infant
  • Lung Diseases, Interstitial/surgery
  • Lung Transplantation/methods
  • Lymphoproliferative Disorders/epidemiology
  • Organ Size
  • Pneumonia, Viral/epidemiology
  • Postoperative Complications/epidemiology
  • Prognosis
  • Referral and Consultation
  • Spain
  • Survival Rate
  • Tissue Donors
  • Tissue and Organ Procurement


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