Abstract
Lung transplantation has become in recent years a therapeutic option for infantswith terminal lung disease with similar results to transplantation in adults.In Spain, since 1996 114 children lung transplants have been performed; this corresponds to3.9% of the total transplant number.The most common indication in children is cystic fibrosis, which represents between 70-80% of the transplants performed in adolescents. In infants common indications areinterstitial lung disease and pulmonary hypertension.In most children a sequential double lung transplant is performed, generally with the help ofextracorporeal circulation. Lung transplantation in children presents special challenges in monitoring and follow-up, especially in infants, given the difficulty in assessing lung function and performing transbronchial biopsies.There are some more specific complications in children like postransplant lymphoproliferative syndrome or a greater severity of respiratory virus infections .After lung transplantation children usually experiment a very important improvement in their quality of life. Eighty eight per cent of children have no limitations in their activity after 3 years of transplantation.According to the registry of the International Society for Heart & Lung Transplantation (ISHLT) survival at 5 years of transplantation is 54% and at 10 years is around 35%.
Original language | English |
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Pages (from-to) | 523-8 |
Number of pages | 6 |
Journal | Archivos de bronconeumologia |
Volume | 49 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2013 |
Keywords
- Adolescent
- Child
- Child, Preschool
- Contraindications
- Cystic Fibrosis/surgery
- Epstein-Barr Virus Infections/complications
- Extracorporeal Circulation
- Graft Rejection/prevention & control
- Graft vs Host Disease/prevention & control
- Humans
- Hypertension, Pulmonary/surgery
- Immunosuppressive Agents/therapeutic use
- Infant
- Lung Diseases, Interstitial/surgery
- Lung Transplantation/methods
- Lymphoproliferative Disorders/epidemiology
- Organ Size
- Pneumonia, Viral/epidemiology
- Postoperative Complications/epidemiology
- Prognosis
- Referral and Consultation
- Spain
- Survival Rate
- Tissue Donors
- Tissue and Organ Procurement