The hydrochlorides of cysteamine, cysteine ethyl ester and penicillamine methyl ester, react with Pd(PPh3)4 to yield low symmetry complexes of palladium(II) that incorporate the N,S-aminothiolato ligand and triphenylphosphine; the complex with cysteine ethyl ester, structurally characterized by X-ray diffraction, proved to be an effective catalyst for the hydrocarboxylation of styrene with high selectivity (98%) towards 2-phenylpropanoic acid.
|Publication status||Published - 7 Feb 1999|
Real, J., Pagès, M., Polo, A., Piniella, J. F., & Álvarez-Larena, Á. (1999). Low symmetry metal complexes: Chloro cysteine ethyl ester-N,S triphenylphosphine palladium(II), a new regioselective hydrocarboxylation catalyst for 2-phenylpropanoic acid, and its crystal structure. Chemical Communications, (3), 277-278. https://doi.org/10.1039/a809130g