A total of 173 samples obtained from adult patients with de novo acute myeloid leukemia (AML) were assayed for exon 3 PTPN11 mutations by single strand conformation polymorphism (SSCP) analysis and direct sequencing. Only three monocytic leukemias had point mutations (1.73%).
|Publication status||Published - 1 Mar 2005|
- Acute myeloid leukemia
- Adults PTPN11
Nomdedéu, J., Carricondo, M. T., Lasa, A., Perea, G., Aventin, A., & Sierra, J. (2005). Low frequency of exon 3 PTPN11 mutations in adult de novo acute myeloid leukemia. Analysis of a consecutive series of 173 patients. Haematologica, 90(3), 412-413.