TY - JOUR
T1 - Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment
AU - Esquerda-Canals, Gisela
AU - Marti, Joaquim
AU - Rivera-Hernández, Geovanny
AU - Giménez-Llort, Lydia
AU - Villegas, Sandra
PY - 2013/9/1
Y1 - 2013/9/1
N2 - The therapeutic potential of scFv-h3D6 has recently been shown in the 3xTg-AD mice. A clear effect on amyloid β (Aβ) oligomers and certain apolipoproteins in the brain was found, but no effect was seen in the cerebellum. Here, cellular vulnerability of the 3xTg-AD cerebellum is described for the first time, together with its protection by scFv-h3D6. Neuron depletion in the DCN was regionally variable and followed a mediolateral axis of involvement that was greatest in the fastigial nucleus, lesser in the interpositus and negligible in the dentate nucleus. A sole and low intraperitoneal dose of scFv-h3D6 protected 3xTg-AD DCN neurons from death. Further studies might provide interesting information about both the potential of scFv-h3D6 as a therapeutic agent and the role of the cerebellum in AD. © 2013 Landes Bioscience.
AB - The therapeutic potential of scFv-h3D6 has recently been shown in the 3xTg-AD mice. A clear effect on amyloid β (Aβ) oligomers and certain apolipoproteins in the brain was found, but no effect was seen in the cerebellum. Here, cellular vulnerability of the 3xTg-AD cerebellum is described for the first time, together with its protection by scFv-h3D6. Neuron depletion in the DCN was regionally variable and followed a mediolateral axis of involvement that was greatest in the fastigial nucleus, lesser in the interpositus and negligible in the dentate nucleus. A sole and low intraperitoneal dose of scFv-h3D6 protected 3xTg-AD DCN neurons from death. Further studies might provide interesting information about both the potential of scFv-h3D6 as a therapeutic agent and the role of the cerebellum in AD. © 2013 Landes Bioscience.
KW - Alzheimer disease
KW - Cerebellum
KW - DCN neurons
KW - Immunotherapy
KW - ScFv-h3D6
U2 - https://doi.org/10.4161/mabs.25428
DO - https://doi.org/10.4161/mabs.25428
M3 - Article
SN - 1942-0862
VL - 5
SP - 660
EP - 664
JO - mAbs
JF - mAbs
IS - 5
ER -