Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment

Gisela Esquerda-Canals, Joaquim Marti, Geovanny Rivera-Hernández, Lydia Giménez-Llort, Sandra Villegas

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

The therapeutic potential of scFv-h3D6 has recently been shown in the 3xTg-AD mice. A clear effect on amyloid β (Aβ) oligomers and certain apolipoproteins in the brain was found, but no effect was seen in the cerebellum. Here, cellular vulnerability of the 3xTg-AD cerebellum is described for the first time, together with its protection by scFv-h3D6. Neuron depletion in the DCN was regionally variable and followed a mediolateral axis of involvement that was greatest in the fastigial nucleus, lesser in the interpositus and negligible in the dentate nucleus. A sole and low intraperitoneal dose of scFv-h3D6 protected 3xTg-AD DCN neurons from death. Further studies might provide interesting information about both the potential of scFv-h3D6 as a therapeutic agent and the role of the cerebellum in AD. © 2013 Landes Bioscience.
Original languageEnglish
Pages (from-to)660-664
JournalmAbs
Volume5
DOIs
Publication statusPublished - 1 Sep 2013

Keywords

  • Alzheimer disease
  • Cerebellum
  • DCN neurons
  • Immunotherapy
  • ScFv-h3D6

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