TY - JOUR
T1 - Long-term wheel running changes on sensorimotor activity and skeletal muscle in male and female mice of accelerated senescence
AU - Sanchez-Roige, Sandra
AU - Lalanza, Jaume F.
AU - Alvarez-López, María Jesús
AU - Cosín-Tomás, Marta
AU - Griñan-Ferré, Christian
AU - Pallàs, Merce
AU - Kaliman, Perla
AU - Escorihuela, Rosa M.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - © 2014, American Aging Association. The senescence-accelerated mouse prone 8 (SAMP8) is considered a useful non-transgenic model for studying aspects of aging. Using SAM resistant 1 (SAMR1) as controls, the long-term effects of wheel running on skeletal muscle adaptations and behavioral traits were evaluated in senescent (P8) and resistant (R1) male and female mice. Long-term wheel running (WR) led to increases in locomotor activity, benefits in sensorimotor function, and changes in body weight in a gender-dependent manner. WR increased body weight and baseline levels of locomotor activity in female mice and improved balance and strength in male mice, compared to sedentary-control mice. WR resulted in key metabolic adaptations in skeletal muscle, associated with an increased activity of the sirtuin 1–AMP-activated protein kinase (AMPK)–PGC-1 alpha axis and changes in vascular endothelial growth factor A (Vegfa), glucose transporter type 4 (Glut4), and Cluster of Differentiation 36 (Cd36) gene expression. Overall, our data indicate that activity, balance, and strength decrease with age and that long-term WR may significantly improve the motor function in a mouse model of senescence in a gender-dependent manner.
AB - © 2014, American Aging Association. The senescence-accelerated mouse prone 8 (SAMP8) is considered a useful non-transgenic model for studying aspects of aging. Using SAM resistant 1 (SAMR1) as controls, the long-term effects of wheel running on skeletal muscle adaptations and behavioral traits were evaluated in senescent (P8) and resistant (R1) male and female mice. Long-term wheel running (WR) led to increases in locomotor activity, benefits in sensorimotor function, and changes in body weight in a gender-dependent manner. WR increased body weight and baseline levels of locomotor activity in female mice and improved balance and strength in male mice, compared to sedentary-control mice. WR resulted in key metabolic adaptations in skeletal muscle, associated with an increased activity of the sirtuin 1–AMP-activated protein kinase (AMPK)–PGC-1 alpha axis and changes in vascular endothelial growth factor A (Vegfa), glucose transporter type 4 (Glut4), and Cluster of Differentiation 36 (Cd36) gene expression. Overall, our data indicate that activity, balance, and strength decrease with age and that long-term WR may significantly improve the motor function in a mouse model of senescence in a gender-dependent manner.
KW - Gender
KW - Metabolism
KW - Motor activity
KW - Sarcopenia
KW - Senescence-accelerated mice
KW - Voluntary wheel running
U2 - 10.1007/s11357-014-9697-1
DO - 10.1007/s11357-014-9697-1
M3 - Article
VL - 36
SP - 9697-
IS - 5
ER -