Long-term treatment with citicoline prevents cognitive decline and predicts a better quality of life after a first ischemic stroke

Jose Alvarez-Sabín, Estevo Santamarina, Olga Maisterra, Carlos Jacas, Carlos Molina, Manuel Quintana

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

© 2016 by the authors; licensee MDPI, Basel, Switzerland. Stroke, as the leading cause of physical disability and cognitive impairment, has a very significant impact on patients’ quality of life (QoL). The objective of this study is to know the effect of citicoline treatment in Qol and cognitive performance in the long-term in patients with a first ischemic stroke. This is an open-label, randomized, parallel study of citicoline vs. usual treatment. All subjects were selected 6 weeks after suffering a first ischemic stroke and randomized into parallel arms. Neuropsychological evaluation was performed at 1 month, 6 months, 1 year and 2 years after stroke, and QoL was measured using the EuroQoL-5D questionnaire at 2 years. 163 patients were followed during 2 years. The mean age was 67.5 years-old, and 50.9% were women. Age and absence of citicoline treatment were independent predictors of both utility and poor quality of life. Patients with cognitive impairment had a poorer QoL at 2 years (0.55 vs. 0.66 in utility, p = 0.015). Citicoline treatment improved significantly cognitive status during follow-up (p = 0.005). In conclusion, treatment with long-term citicoline is associated with a better QoL and improves cognitive status 2 years after a first ischemic stroke.
Original languageEnglish
Article number390
JournalInternational Journal of Molecular Sciences
Volume17
Issue number3
DOIs
Publication statusPublished - 16 Mar 2016

Keywords

  • Citicoline
  • Cognitive impairment
  • Ischemic stroke
  • Quality of life

Fingerprint Dive into the research topics of 'Long-term treatment with citicoline prevents cognitive decline and predicts a better quality of life after a first ischemic stroke'. Together they form a unique fingerprint.

Cite this