Long-Term Normal Renal Function after Drastic Weight Reduction in Patients with Obesity-Related Glomerulopathy

Assumpta Serra, Anna Esteve, Maruja Navarro-Díaz, Dolores López, Ioana Bancu, Ramón Romero

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

© 2015 S. Karger GmbH, Freiburg. Aims: No long-term studies of renal function evolution in morbidly obese (MO) patients after weight loss are available. The aim of our work was to ascertain the long-term influence of drastic weight reduction on renal function in MO patients with obesity-related glomerular lesions. Methods: 92 MO patients with normal renal function and biopsy evidence of mild obesity-related glomerulopathy underwent bariatric surgery (BS) and subsequent drastic weight loss. A long-term prospective follow-up (mean duration: 76 ± 42 months) was carried out. Basal renal biopsies and basal and long-term metabolic and renal function studies were performed in all cases. Linear mixed models were applied. Results: Blood pressure dropped early after BS and remained stable thereafter. Creatinine clearance and BMI fell in the first 2 years, rose slightly after 5 years and then remained stable. Serum creatinine and albuminuria decreased throughout the follow-up period. Renal function and albuminuria evolution showed non-significant differences in relation to the number of glomerular lesions. Conclusions: Drastic weight loss in BS-treated MO patients with pre-surgical normal renal function and mild obesity-related glomerular lesions is associated with short-and long-term maintenance of normal renal function and improvement in both arterial hypertension and albuminuria.
Original languageEnglish
Pages (from-to)188-199
JournalObesity Facts
Volume8
Issue number3
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Bariatric surgery
  • Hypertension
  • Kidney disease
  • Obesity
  • Proteinuria

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