Long-term memory modulation by posttraining epinephrine in rats: Differential effects depending on the basic learning capacity

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Abstract

Effects of posttraining epinephrine on retention of a massed (1 session, 30 trials) 2-way active avoidance task were studied in rats. Immediately after the training session rats received an injection of 0.05 or 0.01 mg/kg ip epinephrine, or distilled water. Retention was tested 11, 20, or 45 days after training, in independent groups of rats. The 20- and 45 day retention was improved in poor-learning rats and disrupted in good-learning rats. It was concluded that the effect (facilitatory or disruptive) of posttraining epinephrine on memory consolidation depends on the basic learning capacity of rats for this task and needs a long time to be expressed.
Original languageEnglish
Pages (from-to)301-308
JournalBehavioral Neuroscience
Volume111
DOIs
Publication statusPublished - 1 Apr 1997

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