TY - JOUR
T1 - Long-term memory modulation by posttraining epinephrine in rats: Differential effects depending on the basic learning capacity
AU - Torras-Garcia, Meritxell
AU - Portell-Cortés, Isabel
AU - Costa-Miserachs, David
AU - Morgado-Bernal, Ignacio
PY - 1997/4/1
Y1 - 1997/4/1
N2 - Effects of posttraining epinephrine on retention of a massed (1 session, 30 trials) 2-way active avoidance task were studied in rats. Immediately after the training session rats received an injection of 0.05 or 0.01 mg/kg ip epinephrine, or distilled water. Retention was tested 11, 20, or 45 days after training, in independent groups of rats. The 20- and 45 day retention was improved in poor-learning rats and disrupted in good-learning rats. It was concluded that the effect (facilitatory or disruptive) of posttraining epinephrine on memory consolidation depends on the basic learning capacity of rats for this task and needs a long time to be expressed.
AB - Effects of posttraining epinephrine on retention of a massed (1 session, 30 trials) 2-way active avoidance task were studied in rats. Immediately after the training session rats received an injection of 0.05 or 0.01 mg/kg ip epinephrine, or distilled water. Retention was tested 11, 20, or 45 days after training, in independent groups of rats. The 20- and 45 day retention was improved in poor-learning rats and disrupted in good-learning rats. It was concluded that the effect (facilitatory or disruptive) of posttraining epinephrine on memory consolidation depends on the basic learning capacity of rats for this task and needs a long time to be expressed.
U2 - 10.1037/0735-7044.111.2.301
DO - 10.1037/0735-7044.111.2.301
M3 - Article
SN - 0735-7044
VL - 111
SP - 301
EP - 308
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
ER -