TY - JOUR
T1 - Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity
AU - Giralt, A.
AU - Puigdellívol, M.
AU - Carretón, O.
AU - Paoletti, P.
AU - Valero, J.
AU - Parra-damas, A.
AU - Saura, C. A.
AU - Alberch, J.
AU - Ginés, S.
PY - 2012/3/1
Y1 - 2012/3/1
N2 - Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder caused by an expanded CAG/polyglutamine repeat in the coding region of the huntingtin (htt) gene. Although HD is classically considered a motor disorder, there is now considerable evidence that early cognitive deficits appear in patients before the onset of motor disturbances. Here we demonstrate early impairment of long-term spatial and recognition memory in heterozygous HD knock-in mutant mice (Hdh Q7/Q111), a genetically accurate HD mouse model. Cognitive deficits are associated with reduced hippocampal expression of CREB-binding protein (CBP) and diminished levels of histone H3 acetylation. In agreement with reduced CBP, the expression of CREB/CBP target genes related to memory, such c-fos, Arc and Nr4a2, was significantly reduced in the hippocampus of Hdh Q7/Q111 mice compared with wild-type mice. Finally, and consistent with a role of CBP in cognitive impairment in Hdh Q7/Q111 mice, administration of the histone deacetylase inhibitor trichostatin A rescues recognition memory deficits and transcription of selective CREB/CBP target genes in Hdh Q7/Q111 mice. These findings demonstrate an important role for CBP in cognitive dysfunction in HD and suggest the use of histone deacetylase inhibitors as a novel therapeutic strategy for the treatment of memory deficits in this disease. © The Author 2011. Published by Oxford University Press. All rights reserved.
AB - Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder caused by an expanded CAG/polyglutamine repeat in the coding region of the huntingtin (htt) gene. Although HD is classically considered a motor disorder, there is now considerable evidence that early cognitive deficits appear in patients before the onset of motor disturbances. Here we demonstrate early impairment of long-term spatial and recognition memory in heterozygous HD knock-in mutant mice (Hdh Q7/Q111), a genetically accurate HD mouse model. Cognitive deficits are associated with reduced hippocampal expression of CREB-binding protein (CBP) and diminished levels of histone H3 acetylation. In agreement with reduced CBP, the expression of CREB/CBP target genes related to memory, such c-fos, Arc and Nr4a2, was significantly reduced in the hippocampus of Hdh Q7/Q111 mice compared with wild-type mice. Finally, and consistent with a role of CBP in cognitive impairment in Hdh Q7/Q111 mice, administration of the histone deacetylase inhibitor trichostatin A rescues recognition memory deficits and transcription of selective CREB/CBP target genes in Hdh Q7/Q111 mice. These findings demonstrate an important role for CBP in cognitive dysfunction in HD and suggest the use of histone deacetylase inhibitors as a novel therapeutic strategy for the treatment of memory deficits in this disease. © The Author 2011. Published by Oxford University Press. All rights reserved.
U2 - https://doi.org/10.1093/hmg/ddr552
DO - https://doi.org/10.1093/hmg/ddr552
M3 - Article
VL - 21
SP - 1203
EP - 1216
JO - Human Molecular Genetics
JF - Human Molecular Genetics
SN - 0964-6906
M1 - ddr552
ER -