Long term improvement in the treatment of canine leishmaniosis using an antimony liposomal formulation

Josep Enric Valladares, Cristina Riera, Pedro González-Ensenyat, Angel Díez-Cascón, Georgina Ramos, Laia Solano-Gallego, Montserrat Gállego, Montserrat Portús, Margarita Arboix, Jordi Alberola

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38 Citations (Scopus)

Abstract

Pharmacokinetic and clinical effectiveness of liposome-encapsulated N-methylglucamine antimoniate (LMA) was performed in dogs suffering from experimental leishmaniosis. LMA was compared with N-methylglucamine antimoniate (MGA), the same drug in its free form. Sb plasma concentrations for LMA were always higher than those for MGA. Mean residence time (MRT), half-life time (t1/2) and clearance (Cl) showed that Sb was eliminated slower after liposome administration. The high volume of distribution (Vd) obtained with LMA suggests that Sb could achieve therapeutic concentrations in parasite-infected tissues. Average plasma concentration at steady state (Cssave) shows that Sb body concentrations after LMA treatment (9.8 mg/kg Sb, each 24 h) would be effective in Leishmania infantum canine infection. Comparing LMA with MGA in a 1-year follow-up we observed no relapses for LMA and total protein and gammaglobulin concentrations were within normal range, while for MGA both began to rise 3 months after treatment. Use of antimonial liposomal formulations may restore effectiveness to an existing drug and reduce toxicity. © 2001 Elsevier Science B.V.
Original languageEnglish
Pages (from-to)15-21
JournalVeterinary Parasitology: Regional Studies and Reports
Volume97
DOIs
Publication statusPublished - 9 May 2001

Keywords

  • Antimony
  • Dog
  • Leishmania infantum
  • Liposomes
  • Meglumine antimoniate

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