Long-term effects of prior cushing’s syndrome

Anna Aulinas, Elena Valassi, Eugenia Resmini, Alicia Santos, Iris Crespo, María José Barahona, Susan M. Webb

Research output: Chapter in BookChapterResearchpeer-review


© Springer International Publishing Switzerland 2017. Cushing’s syndrome, and its most frequent cause pituitary-dependent Cushing’s disease, is a rare disease due to excessive glucocorticoid (GC) secretion. Chronic exposure to GC excess determines a large number of deleterious effects leading to increased morbidity (i.e., cardiovascular complications, psychiatric symptoms, osteoporosis, cognitive impairment, hormonal dysfunctions after surgery) and mortality. Although most of these effects improve after normalization of cortisol, not all are completely reversible after remission of hypercortisolism and negatively impact on health-related quality of life. Therefore, there is a need for both greater diagnostic suspicion and improved diagnostic tools to hasten the delay to diagnosis and effective therapy aimed at improving long-term prognosis. The lack of systematic data analysis and prospective longitudinal studies is due to low prevalence and orphan disease status of CS. Multicenter registries collecting longitudinal data on these patients would contribute to further knowledge on the natural history and longterm outcome data in these patients.
Original languageEnglish
Title of host publicationThe Hypothalamic-Pituitary-Adrenal Axis in Health and Disease: Cushing's Syndrome and Beyond
Number of pages25
Publication statusPublished - 1 Jan 2016


  • Cardiovascular risk
  • Cushing syndrome
  • Hypercortisolism
  • Morbidity
  • Mortality
  • Quality of life
  • Remission


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