TY - JOUR
T1 - Location of the BCR-ABL fusion gene on the 9q34 band in two cases of Ph- positive chronic myeloid leukemia
AU - Aurich, Joan
AU - Dastugue, Nicole
AU - Duchayne, Eliane
AU - Schlaifer, Daniel
AU - Rigal-Huguet, Françoise
AU - Caballin, M. Rosa
PY - 1997/10/1
Y1 - 1997/10/1
N2 - Two new variant Philadelphia (Ph) chromosomes with an aberrant location of the BCR-ABL fusion gene on 9q34 of the derivative 9 are reported. One presented cytogenetically as a standard t(9;22)(q34;qII), whereas the other was classified as an ins(9;22)(q34;q11.1q11.2) using the combined interpretation of cytogenetic, FISH, and molecular data. The mechanisms of the two rearrangements are presented. It is suggested that the insertion has occurred in a single event in the patient with ins(9;22). In the patient with t(9;22), both a translocation and an insertion, occurring either sequentially or simultaneously, can account for the location of the BCR-ABL fusion gene on the derivative 9. A possible poor prognostic impact of this aberrant location of the BCR-ABL is also suggested by the clinical data reported in such patients.
AB - Two new variant Philadelphia (Ph) chromosomes with an aberrant location of the BCR-ABL fusion gene on 9q34 of the derivative 9 are reported. One presented cytogenetically as a standard t(9;22)(q34;qII), whereas the other was classified as an ins(9;22)(q34;q11.1q11.2) using the combined interpretation of cytogenetic, FISH, and molecular data. The mechanisms of the two rearrangements are presented. It is suggested that the insertion has occurred in a single event in the patient with ins(9;22). In the patient with t(9;22), both a translocation and an insertion, occurring either sequentially or simultaneously, can account for the location of the BCR-ABL fusion gene on the derivative 9. A possible poor prognostic impact of this aberrant location of the BCR-ABL is also suggested by the clinical data reported in such patients.
U2 - 10.1002/(SICI)1098-2264(199710)20:2<148::AID-GCC5>3.0.CO;2-3
DO - 10.1002/(SICI)1098-2264(199710)20:2<148::AID-GCC5>3.0.CO;2-3
M3 - Article
VL - 20
SP - 148
EP - 154
JO - Genes Chromosomes and Cancer
JF - Genes Chromosomes and Cancer
SN - 1045-2257
IS - 2
ER -