Location of the BCR-ABL fusion gene on the 9q34 band in two cases of Ph- positive chronic myeloid leukemia

Joan Aurich, Nicole Dastugue, Eliane Duchayne, Daniel Schlaifer, Françoise Rigal-Huguet, M. Rosa Caballin

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27 Citations (Scopus)

Abstract

Two new variant Philadelphia (Ph) chromosomes with an aberrant location of the BCR-ABL fusion gene on 9q34 of the derivative 9 are reported. One presented cytogenetically as a standard t(9;22)(q34;qII), whereas the other was classified as an ins(9;22)(q34;q11.1q11.2) using the combined interpretation of cytogenetic, FISH, and molecular data. The mechanisms of the two rearrangements are presented. It is suggested that the insertion has occurred in a single event in the patient with ins(9;22). In the patient with t(9;22), both a translocation and an insertion, occurring either sequentially or simultaneously, can account for the location of the BCR-ABL fusion gene on the derivative 9. A possible poor prognostic impact of this aberrant location of the BCR-ABL is also suggested by the clinical data reported in such patients.
Original languageEnglish
Pages (from-to)148-154
JournalGenes Chromosomes and Cancer
Volume20
Issue number2
DOIs
Publication statusPublished - 1 Oct 1997

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