Localization of monoamine oxidase A and B and semicarbazide-sensitive amine oxidase in human peripheral tissues

D. Ramonet, M. Rodríguez, J. Saura, J. M. Lizcano, M. Romera, M. Unzeta, C. Finch, E. Billett, N. Mahy

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9 Citations (Scopus)

Abstract

Monoamine oxidase (MAO) A and B and semicarbazide-sensitive amine oxidase (SSAO) localizations in peripheral human tissues were compared by immunohistochemistry. The primary antibodies used were mouse monoclonal anti-human MAO-A (6G11/E1) and anti-human MAO-B (3F12/G10/2E3) and a rabbit polyclonal anti-bovine SSAO antibody. Immunoreactivities of the samples, obtained from 6 routine autopsy cases, showed different distributions in the tissues studied (heart, lung, duodenum, liver, pancreas, spleen, thyroid gland, adrenal gland and kidney). The relative MAO-A, MAO-B and SSAO distributions indicated a widespread distribution of these enzymes in the human body that is characterized by a matching cellular pattern in only few tissues. These differences suggest that each amine oxidase may play a specific function in, at least some, peripheral tissues.
Original languageEnglish
Pages (from-to)111-117
JournalInflammopharmacology
Volume11
Issue number2
DOIs
Publication statusPublished - 16 Jul 2003

Keywords

  • Human
  • Immunohistochemistry
  • Monoamine oxidases
  • Semicarbazide

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