TY - JOUR
T1 - Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults
AU - Marcos-Vidal, Luis
AU - Martínez-García, Magdalena
AU - Martín de Blas, Daniel
AU - Navas-Sánchez, Francisco J.
AU - Pretus, Clara
AU - Ramos-Quiroga, Josep Antoni
AU - Richarte, Vanesa
AU - Vilarroya, Óscar
AU - Sepulcre, Jorge
AU - Desco, Manuel
AU - Carmona, Susanna
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Ministerio de Ciencia, Innovación y Universidades project RTI2018-093952-B-100 and by Instituto de Salud Carlos III projects CPII21/00016 and PI17/00064, and co-funded by European Regional Development Fund (ERDF), “A way of making Europe.” MMG was funded by Ministerio de Ciencia, Innovación y Universidades, Instituto de Salud Carlos III, Predoctorales de Formación en Investigación en Salud (PFIS) (contract FI18/00255) and a predoctoral Fulbright grant and SC was funded by a Miguel Servet Type II research contract (CPII21/00016). MMG and SC were co-funded by European Social Fund “Investing in your future.” The project leading to these results has received funding from “la Caixa” Foundation under the project code LCF/PR/HR19/52160001, from the European Research Council (ERC) under the “European Union’s Horizon 2020" research and innovation programme (grant agreement No 883069), and from the Centro Nacional de Investigaciones Cardiovasculares (CNIC). The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-050).
Publisher Copyright:
© ©The Author(s) 2022.
PY - 2022
Y1 - 2022
N2 - Objective: Neuroimaging studies in children with ADHD indicate that their brain exhibits an atypical functional connectivity pattern characterized by increased local connectivity and decreased distant connectivity. We aim to evaluate if the local and distant distribution of functional connectivity is also altered in adult samples with ADHD who have never received medication before. Methods: We compared local and distant functional connectivity between 31 medication-naïve adults with ADHD and 31 healthy controls and tested whether this pattern was associated with symptoms severity scores. Results: ADHD sample showed increased local connectivity in the dACC and the SFG and decreased local connectivity in the PCC. Conclusion: Results parallel those obtained in children samples suggesting a deficient integration within the DMN and segregation between DMN, FPN, and VAN. These results are consistent with the three main frameworks that explain ADHD: the neurodevelopmental delay hypothesis, the DMN interference hypothesis, and multi-network models.
AB - Objective: Neuroimaging studies in children with ADHD indicate that their brain exhibits an atypical functional connectivity pattern characterized by increased local connectivity and decreased distant connectivity. We aim to evaluate if the local and distant distribution of functional connectivity is also altered in adult samples with ADHD who have never received medication before. Methods: We compared local and distant functional connectivity between 31 medication-naïve adults with ADHD and 31 healthy controls and tested whether this pattern was associated with symptoms severity scores. Results: ADHD sample showed increased local connectivity in the dACC and the SFG and decreased local connectivity in the PCC. Conclusion: Results parallel those obtained in children samples suggesting a deficient integration within the DMN and segregation between DMN, FPN, and VAN. These results are consistent with the three main frameworks that explain ADHD: the neurodevelopmental delay hypothesis, the DMN interference hypothesis, and multi-network models.
KW - ADHD
KW - adults
KW - brain networks
KW - functional connectivity
KW - neurodevelopment
KW - resting state
UR - http://www.scopus.com/inward/record.url?scp=85131763055&partnerID=8YFLogxK
U2 - 10.1177/10870547221101646
DO - 10.1177/10870547221101646
M3 - Article
C2 - 35684934
AN - SCOPUS:85131763055
JO - Journal of Attention Disorders
JF - Journal of Attention Disorders
SN - 1087-0547
ER -