TY - JOUR
T1 - Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults
AU - Marcos-Vidal, Luis
AU - Martínez-García, Magdalena
AU - Martín de Blas, Daniel
AU - Navas-Sánchez, Francisco J.
AU - Pretus, Clara
AU - Ramos-Quiroga, Josep Antoni
AU - Richarte, Vanesa
AU - Vilarroya, Óscar
AU - Sepulcre, Jorge
AU - Desco, Manuel
AU - Carmona, Susanna
N1 - Publisher Copyright:
© ©The Author(s) 2022.
PY - 2022/11
Y1 - 2022/11
N2 - Objective: Neuroimaging studies in children with ADHD indicate that their brain exhibits an atypical functional connectivity pattern characterized by increased local connectivity and decreased distant connectivity. We aim to evaluate if the local and distant distribution of functional connectivity is also altered in adult samples with ADHD who have never received medication before. Methods: We compared local and distant functional connectivity between 31 medication-naïve adults with ADHD and 31 healthy controls and tested whether this pattern was associated with symptoms severity scores. Results: ADHD sample showed increased local connectivity in the dACC and the SFG and decreased local connectivity in the PCC. Conclusion: Results parallel those obtained in children samples suggesting a deficient integration within the DMN and segregation between DMN, FPN, and VAN. These results are consistent with the three main frameworks that explain ADHD: the neurodevelopmental delay hypothesis, the DMN interference hypothesis, and multi-network models.
AB - Objective: Neuroimaging studies in children with ADHD indicate that their brain exhibits an atypical functional connectivity pattern characterized by increased local connectivity and decreased distant connectivity. We aim to evaluate if the local and distant distribution of functional connectivity is also altered in adult samples with ADHD who have never received medication before. Methods: We compared local and distant functional connectivity between 31 medication-naïve adults with ADHD and 31 healthy controls and tested whether this pattern was associated with symptoms severity scores. Results: ADHD sample showed increased local connectivity in the dACC and the SFG and decreased local connectivity in the PCC. Conclusion: Results parallel those obtained in children samples suggesting a deficient integration within the DMN and segregation between DMN, FPN, and VAN. These results are consistent with the three main frameworks that explain ADHD: the neurodevelopmental delay hypothesis, the DMN interference hypothesis, and multi-network models.
KW - ADHD
KW - adults
KW - brain networks
KW - functional connectivity
KW - neurodevelopment
KW - resting state
KW - Brain Mapping/methods
KW - Humans
KW - Magnetic Resonance Imaging/methods
KW - Neural Pathways
KW - Brain/diagnostic imaging
KW - Adult
KW - Child
KW - Attention Deficit Disorder with Hyperactivity/diagnosis
KW - DEFAULT MODE NETWORK
KW - MATTER
KW - DEFICIT HYPERACTIVITY DISORDER
KW - ANTERIOR CINGULATE
KW - CHILDREN
KW - ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
KW - CORTEX
KW - MOTOR
KW - BOYS
KW - BRAIN NETWORKS
UR - http://www.scopus.com/inward/record.url?scp=85131763055&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/de5ecabe-0973-3294-8f1d-fbb2d2d665db/
U2 - 10.1177/10870547221101646
DO - 10.1177/10870547221101646
M3 - Article
C2 - 35684934
AN - SCOPUS:85131763055
SN - 1087-0547
VL - 26
SP - 1788
EP - 1801
JO - Journal of Attention Disorders
JF - Journal of Attention Disorders
IS - 13
M1 - 10870547221101646
ER -