Local dopaminergic modulation of the motor activity induced by N-methyl-D-aspartate receptor stimulation in the ventral hippocampus

Lydia Giménez-Llort, Fu Hua Wang, Sven Ove Ögren, Sergi Ferré

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Dopaminergic neurotransmission has been implicated in the motor activating effects induced by the local infusion of NMDA in the ventral hippocampus (VH). The nucleus accumbens and the ventral tegmental area (VTA) have been proposed to be the main loci where dopamine is acting as a positive modulator of the VH NMDA receptor-mediated motor activating effects. However, the existence of a relatively high dopamine innervation and dopamine receptor density in the VH suggests the possibility of local dopamine/NMDA receptor interactions. This hypothesis was tested by studying the effects of the bilateral local VH infusion of NMDA (0.05, 0.1, 0.5 and 1.0 μg/side), the dopamine D1/D5 receptor antagonist SCH 23390 (1 μg/side) and the dopamine D2 receptor antagonist raclopride (1 and 5 μg/side). Neither SCH 23390 nor raclopride induced any significant change in motor activity compared with the vehicle control group, but both compounds significantly antagonized the motor activation induced by NMDA. SCH 23390 (1 μg/side) was more potent that raclopride (minimal effective dose: 5 μg/side). These results demonstrate the existence of a strong tonic facilitating effect of dopamine, acting preferentially at dopamine D1/D5 receptors, on NMDA receptor-mediated effects in the VH. © 2002 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
Original languageEnglish
Pages (from-to)737-743
JournalNeuropsychopharmacology
Volume26
DOIs
Publication statusPublished - 9 May 2002

Keywords

  • Dopamine D1 receptor
  • Dopamine D2 receptor
  • General motor activity
  • Glutamate
  • Locomotor activity
  • Rearing

Fingerprint Dive into the research topics of 'Local dopaminergic modulation of the motor activity induced by N-methyl-D-aspartate receptor stimulation in the ventral hippocampus'. Together they form a unique fingerprint.

Cite this