Liver, Brain, and Heart Metallothionein Induction by Stress

Juan Hidalgo*, Marta Borrás, Justine S. Garvey, Antonio Armario

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    76 Citations (Scopus)


    To date, stress has been reported to induce metallothionein (MT) synthesis in the liver only. In the present experiment, the effects of food and water deprivation alone or of immobilization stress plus food and water deprivation on liver, brain, and heart MT have been studied in adult male rats. Liver and brain MT levels were increased by immobilization stress as soon as 6 h after the onset of stress. Eighteen hours of immobilization, which is accompanied by food and water deprivation, further increased liver and brain MT levels and significantly increased heart MT content. A specific effect of immobilization was evident in all three tissues, because the effect of food and water deprivation alone was significantly lower than that of immobilization plus starvation. Changes in MT apparently were not related to changes in cytosolic Zn. Copyright © 1990, Wiley Blackwell. All rights reserved
    Original languageEnglish
    Pages (from-to)651-654
    JournalJournal of Neurochemistry
    Publication statusPublished - 1 Jan 1990


    • Brain
    • Heart
    • Liver
    • Metallothionein
    • Stress
    • Zinc metabolism.


    Dive into the research topics of 'Liver, Brain, and Heart Metallothionein Induction by Stress'. Together they form a unique fingerprint.

    Cite this