Liver biopsy-related infection in liver transplant recipients: A current matter of concern?

Cristina Lõpez Sánchez, Oscar Len, Joan Gavalda, Itxarone Bilbao, Lluis Castells, Maria Arantzazu Gelabert, Helena Allende, Albert Pahissa

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Data from published studies regarding risk factors for liver biopsy (LB)-related infectious complications in liver transplant recipients are inconsistent. We carried out a retrospective cohort study analyzing consecutive LBs for orthotopic liver transplant patients at a tertiary hospital (2001-2011): there were 667 LB procedures (575 percutaneous procedures and 92 transjugular procedures) in 286 liver transplant recipients. There were 20 complications in 19 patients (overall incidence=3.0%): 10 were infectious complications (8 cases of bacteremia and 2 cases of peritonitis). The causal microorganisms were mainly Pseudomonas aeruginosa (4 patients) and Enterobacteriaceae (4 patients). All complications occurred with biopsies performed in patients hospitalized for more than 48 hours (381 biopsies for 201 patients); hence, only this group was included in the risk factor analysis. The variables associated with the development of infectious complications after LB were the presence of impaired biliary drainage at the time of biopsy (40% versus 15.1%, P=0.03) and low albumin levels (2.4 versus 3.1 g/dL, P=0.01). In conclusion, according to our experience, infectious complications secondary to LB in liver transplant recipients are related to hospitalization at the time of biopsy, particularly in the presence of impaired biliary drainage and low albumin levels. © 2014 American Association for the Study of Liver Diseases.
Original languageEnglish
Pages (from-to)552-556
JournalLiver Transplantation
Volume20
Issue number5
DOIs
Publication statusPublished - 1 Jan 2014

Fingerprint Dive into the research topics of 'Liver biopsy-related infection in liver transplant recipients: A current matter of concern?'. Together they form a unique fingerprint.

Cite this