Littoral cell angioma with severe thrombocytopenia

I. Español, E. Lerma, V. Fumanal, J. Palmer, M. Roca, A. Domingo-Albó, N. Pujol-Moix

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19 Citations (Scopus)


Littoral cell angioma (LCA) is a recently described splenic vascular tumor. We present a new case in a 62-year-old woman with severe thrombocytopenia and mild bleeding diathesis, but without palpable splenomegaly. Abdominal ultrasound and magnetic resonance showed multiple nodular images, suggesting splenic hemangiomas. A platelet kinetic study revealed a very short platelet survival. As the spleen was the site of platelet destruction, splenectomy was carried out. Histopathological and immunohistochemical data allowed a final diagnosis of LCA. Following splenectomy, the patient showed a transitory normalization-of the platelet counts. Thrombocytopenia then reappeared but was moderate, without hemorrhagic diathesis. A second platelet kinetic study, performed 16 months post-splenectomy, showed hepatic platelet destruction. However, there were no macroscopic hepatic lesions in a second abdominal magnetic resonance study. This case illustrates the difficulties involved in determining the etiology of many peripheral thrombocytopenias.
Original languageEnglish
Pages (from-to)46-49
JournalAnnals of Hematology
Issue number1
Publication statusPublished - 1 Jan 2000


  • Autoimmune thrombocytopenic purpura
  • Littoral cell angioma
  • Spleen
  • Thrombocytopenia


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