Liraglutide in the treatment of Type 2 diabetes: Clinical data and practical considerations for its use

Francisco Javier Ampudia-Blasco, Carlos Calvo Gmez, Xavier Cos Claramunt, Javier Garca Alegra, Esteban Jdar Gimeno, José Javier Mediavilla Bravo, Pedro Mezquita Raya, Jorge Navarro Pérez, Manel Puig Domingo

Research output: Contribution to journalReview articleResearchpeer-review

1 Citation (Scopus)

Abstract

Liraglutide is the first once-daily human glucagon-like peptide-1 analog available for use in clinical practice. It has recently been approved by the EMA and the US FDA for treatment of Type 2 diabetes mellitus (T2DM). Initial approval is for use in combination with either metformin or a sulfonylurea, or in combination with metformin plus a sulfonylurea or thiazolidinedione. Liraglutide monotherapy is approved in the USA. Results from the Liraglutide Effect and Action in Diabetes (LEAD) clinical trials program indicate that liraglutide significantly lowers glycosylated hemoglobin (HbA1c) with a low risk of hypoglycemia. Liraglutide is also associated with significant and sustained weight loss, decreased systolic blood pressure, and improvements in other markers of cardiovascular risk. Liraglutide also shows strong potential to preserve-cell function. Maximum benefits may be achieved when liraglutide treatment is initiated early on in the course of T2DM. © 2010 Expert Reviews Ltd.
Original languageEnglish
Pages (from-to)799-807
JournalExpert Review of Endocrinology and Metabolism
Volume5
Issue number6
DOIs
Publication statusPublished - 1 Nov 2010

Keywords

  • GLP-1 analog
  • glycemic control
  • incretin
  • liraglutide
  • Type 2 diabetes mellitus

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