Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma

Tuna Toptan; Marion G. Brusadelli; Brian Turpin; David P. Witte; Jordi Surrallés; Eunike Velleuer; Martin Schramm; Ralf Dietrich; Ruud H. Brakenhoff; Patrick S. Moore; Yuan Chang; Susanne I. Wells

doi:10.1371/journal.pone.0209235

Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma

Tuna Toptan, Marion G. Brusadelli, Brian Turpin, David P. Witte, Jordi Surrallés, Eunike Velleuer, Martin Schramm, Ralf Dietrich, Ruud H. Brakenhoff, Patrick S. Moore, Yuan Chang, Susanne I. Wells

Department of Genetics and Microbiology

Research output: Contribution to journal › Article › Research

2 Citations (Scopus)

Abstract

© 2018 Toptan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fanconi anemia is a rare genome instability disorder with extreme susceptibility to squamous cell carcinoma of the head and neck and anogenital tract. In patients with this inherited disorder, the risk of head and neck cancer is 800-fold higher than in the general population, a finding which might suggest a viral etiology. Here, we analyzed the possible contribution of human polyomaviruses to FA-associated head and neck squamous cell carcinoma (HNSCC) by a pan-polyomavirus immunohistochemistry test which detects the T antigens of all known human polyomaviruses. We observed weak reactivity in 17% of the HNSCC samples suggesting that based on classical criteria, human polyomaviruses are not causally related to squamous cell carcinomas analyzed in this study.

Original language	English
Article number	e0209235
Journal	PLoS ONE
Volume	13
DOIs	https://doi.org/10.1371/journal.pone.0209235
Publication status	Published - 1 Dec 2018

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Toptan, T., Brusadelli, M. G., Turpin, B., Witte, D. P., Surrallés, J., Velleuer, E., Schramm, M., Dietrich, R., Brakenhoff, R. H., Moore, P. S., Chang, Y., & Wells, S. I. (2018). Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma. PLoS ONE, 13, [e0209235]. https://doi.org/10.1371/journal.pone.0209235

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title = "Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma",

abstract = "{\textcopyright} 2018 Toptan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fanconi anemia is a rare genome instability disorder with extreme susceptibility to squamous cell carcinoma of the head and neck and anogenital tract. In patients with this inherited disorder, the risk of head and neck cancer is 800-fold higher than in the general population, a finding which might suggest a viral etiology. Here, we analyzed the possible contribution of human polyomaviruses to FA-associated head and neck squamous cell carcinoma (HNSCC) by a pan-polyomavirus immunohistochemistry test which detects the T antigens of all known human polyomaviruses. We observed weak reactivity in 17% of the HNSCC samples suggesting that based on classical criteria, human polyomaviruses are not causally related to squamous cell carcinomas analyzed in this study.",

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Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma. / Toptan, Tuna; Brusadelli, Marion G.; Turpin, Brian; Witte, David P.; Surrallés, Jordi; Velleuer, Eunike; Schramm, Martin; Dietrich, Ralf; Brakenhoff, Ruud H.; Moore, Patrick S.; Chang, Yuan; Wells, Susanne I.

In: PLoS ONE, Vol. 13, e0209235, 01.12.2018.

Research output: Contribution to journal › Article › Research

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AU - Dietrich, Ralf

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AB - © 2018 Toptan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fanconi anemia is a rare genome instability disorder with extreme susceptibility to squamous cell carcinoma of the head and neck and anogenital tract. In patients with this inherited disorder, the risk of head and neck cancer is 800-fold higher than in the general population, a finding which might suggest a viral etiology. Here, we analyzed the possible contribution of human polyomaviruses to FA-associated head and neck squamous cell carcinoma (HNSCC) by a pan-polyomavirus immunohistochemistry test which detects the T antigens of all known human polyomaviruses. We observed weak reactivity in 17% of the HNSCC samples suggesting that based on classical criteria, human polyomaviruses are not causally related to squamous cell carcinomas analyzed in this study.

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