TY - JOUR
T1 - Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma
AU - Toptan, Tuna
AU - Brusadelli, Marion G.
AU - Turpin, Brian
AU - Witte, David P.
AU - Surrallés, Jordi
AU - Velleuer, Eunike
AU - Schramm, Martin
AU - Dietrich, Ralf
AU - Brakenhoff, Ruud H.
AU - Moore, Patrick S.
AU - Chang, Yuan
AU - Wells, Susanne I.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - © 2018 Toptan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fanconi anemia is a rare genome instability disorder with extreme susceptibility to squamous cell carcinoma of the head and neck and anogenital tract. In patients with this inherited disorder, the risk of head and neck cancer is 800-fold higher than in the general population, a finding which might suggest a viral etiology. Here, we analyzed the possible contribution of human polyomaviruses to FA-associated head and neck squamous cell carcinoma (HNSCC) by a pan-polyomavirus immunohistochemistry test which detects the T antigens of all known human polyomaviruses. We observed weak reactivity in 17% of the HNSCC samples suggesting that based on classical criteria, human polyomaviruses are not causally related to squamous cell carcinomas analyzed in this study.
AB - © 2018 Toptan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fanconi anemia is a rare genome instability disorder with extreme susceptibility to squamous cell carcinoma of the head and neck and anogenital tract. In patients with this inherited disorder, the risk of head and neck cancer is 800-fold higher than in the general population, a finding which might suggest a viral etiology. Here, we analyzed the possible contribution of human polyomaviruses to FA-associated head and neck squamous cell carcinoma (HNSCC) by a pan-polyomavirus immunohistochemistry test which detects the T antigens of all known human polyomaviruses. We observed weak reactivity in 17% of the HNSCC samples suggesting that based on classical criteria, human polyomaviruses are not causally related to squamous cell carcinomas analyzed in this study.
U2 - https://doi.org/10.1371/journal.pone.0209235
DO - https://doi.org/10.1371/journal.pone.0209235
M3 - Article
C2 - 30589865
VL - 13
M1 - e0209235
ER -
