Levels of coagulation inhibitors and thrombin-antithrombin III complexes in normal pregnancy

J. Bellart, R. Gilabert, J. Fontcuberta, M. Borrell, R. M. Miralles, L. Cabero

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

We evaluated changes in plasma coagulation inhibitors and thrombin-antithrombin III complexes in 60 normal pregnant women. Blood samples were taken on the first, second and third trimesters, during delivery and 3 days after delivery. Antithrombin III, thrombin-antithrombin III, heparin cofactor II, protein C and protein S were determined using commercial tests. Antithrombin III remained unchanged during pregnancy, but increased after delivery. Heparin cofactor II levels during pregnancy were above non-pregnant values, but returned to normal non-pregnant values at delivery. Protein C decreased during delivery, but protein S levels decreased from the second trimester and returned to normal non-pregnant values during delivery. High thrombin-antithrombin III levels showed that the coagulation system was activated during pregnancy from the first trimester. Maximum levels were reached during delivery. Three days after delivery, the coagulation inhibitors returned to normal non-pregnant values.
Original languageEnglish
Pages (from-to)699-702
JournalMedical Science Research
Volume25
Issue number10
Publication statusPublished - 20 Nov 1997

Keywords

  • Antithrombin III
  • Coagulation
  • Heparin cofactor II
  • Pregnancy
  • Protein C
  • Protein S
  • Thrombin-antithrombin III complexes

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