Learning deficits in an odor reward-task induced by parafascicular thalamic lesions are ameliorated by pretraining d-cycloserine in the prelimbic cortex

Irene Villarejo-Rodríguez; Pere Boadas-Vaello; Marta Portero-Tresserra; Anna Vale-Martínez; Margarita Martí-Nicolovius; Gemma Guillazo-Blanch

doi:https://doi.org/10.1016/j.bbr.2012.10.041

Learning deficits in an odor reward-task induced by parafascicular thalamic lesions are ameliorated by pretraining d-cycloserine in the prelimbic cortex

Irene Villarejo-Rodríguez, Pere Boadas-Vaello, Marta Portero-Tresserra, Anna Vale-Martínez, Margarita Martí-Nicolovius, Gemma Guillazo-Blanch

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

We investigated whether the N-methyl- d-aspartate (NMDA) receptor partial agonist d-cycloserine (DCS) infused into the prelimbic cortex (PLC) would reverse the learning deficits caused by bilateral excitotoxic lesions of the parafascicular nucleus (PFn) in an odor discrimination task (ODT). Rats with PFn lesions received a bilateral infusion of DCS (10 μg/side) into the PLC 20. min before ODT acquisition. The task retention was evaluated in a drug-free test carried out 24. h later. DCS significantly attenuated the PFn lesion-induced deficits as measured by both latency to nose-poke the rewarded odor and number of errors committed during ODT acquisition and retention. Therefore, DCS may be an enhancing memory treatment in animal models of cognitive impairment, such as PFn-lesioned rats. The PFn contribution to learning and memory may possibly be linked to its role in the modulation of glutamatergic PLC activity. © 2012 Elsevier B.V.

Original language	English
Pages (from-to)	289-292
Journal	Behavioural Brain Research
Volume	238
DOIs	https://doi.org/10.1016/j.bbr.2012.10.041
Publication status	Published - 1 Feb 2013

Keywords

Glutamate
Intralaminar nuclei
NMDA receptors
Odor learning
Prefrontal cortex
Thalamus

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Villarejo-Rodríguez, I., Boadas-Vaello, P., Portero-Tresserra, M., Vale-Martínez, A., Martí-Nicolovius, M., & Guillazo-Blanch, G. (2013). Learning deficits in an odor reward-task induced by parafascicular thalamic lesions are ameliorated by pretraining d-cycloserine in the prelimbic cortex. Behavioural Brain Research, 238, 289-292. https://doi.org/10.1016/j.bbr.2012.10.041

Villarejo-Rodríguez, Irene ; Boadas-Vaello, Pere ; Portero-Tresserra, Marta ; Vale-Martínez, Anna ; Martí-Nicolovius, Margarita ; Guillazo-Blanch, Gemma. / Learning deficits in an odor reward-task induced by parafascicular thalamic lesions are ameliorated by pretraining d-cycloserine in the prelimbic cortex. In: Behavioural Brain Research. 2013 ; Vol. 238. pp. 289-292.

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abstract = "We investigated whether the N-methyl- d-aspartate (NMDA) receptor partial agonist d-cycloserine (DCS) infused into the prelimbic cortex (PLC) would reverse the learning deficits caused by bilateral excitotoxic lesions of the parafascicular nucleus (PFn) in an odor discrimination task (ODT). Rats with PFn lesions received a bilateral infusion of DCS (10 μg/side) into the PLC 20. min before ODT acquisition. The task retention was evaluated in a drug-free test carried out 24. h later. DCS significantly attenuated the PFn lesion-induced deficits as measured by both latency to nose-poke the rewarded odor and number of errors committed during ODT acquisition and retention. Therefore, DCS may be an enhancing memory treatment in animal models of cognitive impairment, such as PFn-lesioned rats. The PFn contribution to learning and memory may possibly be linked to its role in the modulation of glutamatergic PLC activity. {\textcopyright} 2012 Elsevier B.V.",

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author = "Irene Villarejo-Rodr{\'i}guez and Pere Boadas-Vaello and Marta Portero-Tresserra and Anna Vale-Mart{\'i}nez and Margarita Mart{\'i}-Nicolovius and Gemma Guillazo-Blanch",

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Villarejo-Rodríguez, I, Boadas-Vaello, P, Portero-Tresserra, M , Vale-Martínez, A , Martí-Nicolovius, M & Guillazo-Blanch, G 2013, 'Learning deficits in an odor reward-task induced by parafascicular thalamic lesions are ameliorated by pretraining d-cycloserine in the prelimbic cortex', Behavioural Brain Research, vol. 238, pp. 289-292. https://doi.org/10.1016/j.bbr.2012.10.041

Learning deficits in an odor reward-task induced by parafascicular thalamic lesions are ameliorated by pretraining d-cycloserine in the prelimbic cortex. / Villarejo-Rodríguez, Irene; Boadas-Vaello, Pere; Portero-Tresserra, Marta ; Vale-Martínez, Anna ; Martí-Nicolovius, Margarita ; Guillazo-Blanch, Gemma.

In: Behavioural Brain Research, Vol. 238, 01.02.2013, p. 289-292.

Research output: Contribution to journal › Article › Research › peer-review

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