Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: The GENOMOS study

Bente L. Langdahl, André G. Uitterlinden, Stuart H. Ralston, Thomas A. Trikalinos, Susanne Balcells, Maria Luisa Brandi, Serena Scollen, Paul Lips, Roman Lorenc, Barbara Obermayer-Pietsch, David M. Reid, Jácome Bruges Armas, Pascal P. Arp, Amelia Bassiti, Mariona Bustamante, Lise Bjerre Husted, Alison H. Carey, Ramon Pérez Cano, Harald Dobnig, Alison M. DunningAstrid Fahrleitner-Pammer, Alberto Falchetti, Elzbieta Karczmarewicz, Marcin Kruk, Johannes P.T.M. van Leeuwen, Laura Masi, Joyce B.J. van Meurs, Jon Mangion, Fiona E.A. McGuigan, Leonardo Mellibovsky, Leif Mosekilde, Xavier Nogués, Huibert A.P. Pols, Jonathan Reeve, Wilfried Renner, Fernando Rivadeneira, Natasja M. van Schoor, John P.A. Ioannidis

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Abstract

Introduction: The TGFB1 gene which encodes transforming growth factor beta 1, is a strong candidate for susceptibility to osteoporosis and several studies have reported associations between bone mineral density (BMD), osteoporotic fractures and polymorphisms of TGFB1, although these studies have yielded conflicting results. Methods: We investigated associations between TGFB1 polymorphisms and BMD and fracture in the GENOMOS study: a prospective multicenter study involving 10 European research studies including a total of 28,924 participants. Genotyping was conducted for known TGFB1 polymorphisms at the following sites: G- 1639-A (G- 800-A, rs1800468), C- 1348-T (C- 509-T, rs1800469), T29-C (Leu10Pro, rs1982073), G74-C (Arg25Pro, rs1800471) and C788-T (Thr263Ile, rs1800472). These polymorphisms were genotyped prospectively and methodology was standardized across research centers. Genotypes and haplotypes were related to BMD at the lumbar sine and femoral neck and fractures. Results: There were no significant differences in either women or men at either skeletal site for any of the examined polymorphisms with the possible exception of a weak association with reduced BMD (- 12 mg/cm2) in men with the T- 1348 allele (p < 0.05). None of the haplotypes was associated with BMD and none of the polymorphisms or haplotypes significantly affected overall risk of fractures, however, the odds ratio for incident vertebral fracture in carriers of the rare T788 allele was 1.64 (95% CI: 1.09-2.64), p < 0.05. Conclusions: This study indicates that polymorphic variation in the TGFB1 gene does not play a major role in regulating BMD or susceptibility to fractures. The weak associations we observed between the C- 1348-T and lumbar spine BMD in men and between C788-T and risk of incident vertebral fractures are of interest but could be chance findings and will need replication in future studies. © 2007 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)969-981
JournalBone
Volume42
Issue number5
DOIs
Publication statusPublished - 1 May 2008

Keywords

  • Bone mineral density
  • Fracture
  • Meta-analysis
  • Osteoporosis
  • Transforming growth factor beta 1

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