Lack of PrPsc immunostaining in intracranial ectopic lymphoid follicles in a sheep with concomitant non-suppurative encephalitis and Nor98-like atypical scrapie: A case report

Marti Pumarola Batlle, Olga Francino Martí, Enric Vidal Barba, R. Tortosa, C. Costa, J. Benavides, E. Sánchez-Robert, V. Pérez

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9 Citations (Scopus)

Abstract

During active surveillance for transmissible spongiform encephalopathies (TSEs) in sheep, an initial reactor was detected using a rapid test on a brain sample. Immunohistochemistry confirmed an atypical TSE presentation that closely resembled the previously described Nor98 cases. Sequencing of the prnp gene confirmed the ARQ/AHQ genotype with the L141F mutation at codon 141 associated with this phenotype. The head, including the brain and cranial lymphoid tissues, was sampled and examined thoroughly. Non-purulent encephalitis, with ectopic lymphoid follicle formation within the brain, was diagnosed concomitant to the TSE. When scrapie-associated prion protein (PrPsc) deposition was studied by immunohistochemistry there was a noticeable lack of lymphotropism. The distribution of PrPsc in the brain differed considerably from that of classical scrapie cases. Astrogliosis and microgliosis were demonstrated by histochemical procedures. © 2007 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)283-288
JournalVeterinary Journal
Volume177
Issue number2
DOIs
Publication statusPublished - 1 Aug 2008

Keywords

  • Atypical scrapie
  • Lymphotropism
  • Ovine
  • PrP sc

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