Lack of association of SDF-1 3′ A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years

Francesc Vidal*, Joaquim Peraire, Pere Domingo, Montserrat Broch, Hernando Knobel, Enric Pedrol, David Dalmau, Consuelo Viladés, Antònia Sambeat, Cristina Gutiérrez, Cristóbal Richart

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

We studied the frequency of the SDF-1 3′ A allelic variant (80IG→A) in a cohort of white Spaniards made up of (1) HIV-1-infected long-term nonprogressors (LTNPs) older than 16 years of age (n = 57), (2) HIV-1-infected usual progressors (UPs; n = 107). and (3) a group of healthy controls (n = 100). The mutant SDF-1 3′ A allele was observed in 28% of LTNPs, 19% of UPs. and 26% of healthy controls (P = not significant). Homozygosity for the 3′ A mutation was detected in 7%. 4%, and 3% of LTNPs, UPs, and healthy controls, respectively (P = not significant). Polymorphism at the SDF-1 locus is not associated with LTNP disease of longer than 16 years in Spanish HIV-1-infected patients. This effect is independent of the CCR5Δ32 allele.

Original languageAmerican English
Pages (from-to)276-279
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume40
Issue number3
DOIs
Publication statusPublished - 1 Nov 2005

Keywords

  • CCR5Δ32
  • Genetic polymorphism
  • HIV-1 infection
  • Long-term nonprogressors
  • SDF-1 3′ A

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